Details About Generic Salt ::  Sulfinpy

Main Medicine Class:: Uricosuric,gout   

(sull-fin-PEER-uh-zone)
Anturane, Sulfinpyrazone,  Novo-Pyrazone
Class: Uricosuric/gout

 

Drugs Class ::

 Action Potent uricosuric agent that inhibits renal tubular reabsorption of uric acid and reduces renal tubular secretion of other organic anions; possesses antithrombotic and platelet-inhibiting effects.

Indications for Drugs ::

 Indications Treatment of chronic and intermittent gouty arthritis. Not intended for relief of acute attack of gout. unlabeled use(s): Post MI treatment (within 1 to 6 mo of acute MI) to decrease incidence of sudden cardiac death. May also be used to reduce frequency of systemic embolism in rheumatic mitral stenosis.

Drug Dose ::

 Route/Dosage

ADULTS: PO Initial: 200 to 400 mg daily in 2 divided doses with meals or milk, gradually increasing to full maintenance dosage in 1 wk. Maintenance: 200 to 800 mg daily, given in 2 divided doses; may increase or decrease after serum urate level is controlled. In case of acute exacerbations, administer concomitant treatment with indomethacin (or another NSAID) or colchicine.

Contraindication ::

 Contraindications Active peptic ulcer or symptoms of GI inflammation or ulceration; hypersensitivity to phenylbutazone or other pyrazoles; blood dyscrasias.

Drug Precautions ::

 Precautions

Pregnancy: Use only when clearly needed. Lactation: Undetermined. Children: Safety and efficacy not established. Alkalinization of urine: Sulfinpyrazone use may precipitate acute gouty arthritis, urolithiasis and renal colic. Adequate fluid intake (10 to 12 8 oz glasses of fluid) and alkalinization of urine are recommended to reduce potential for renal complications. Healed peptic ulcer: Administer with care to these patients. Renal function impairment: Periodically assess renal function.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

DERM: Rash. GI: Nausea; vomiting; epigastric distress. HEMA: Blood dyscrasias, including anemia; leukopenia; agranulocytosis; thrombocytopenia; aplastic anemia. RESP: Bronchoconstriction (in aspirin-sensitive patients).

Drug Mode of Action ::  

 Action Potent uricosuric agent that inhibits renal tubular reabsorption of uric acid and reduces renal tubular secretion of other organic anions; possesses antithrombotic and platelet-inhibiting effects.

Drug Interactions ::

 Interactions

Acetaminophen: Increased hepatotoxicity and reduced efficacy of acetaminophen may occur. Anticoagulants, sulfonylureas (eg, tolbutamide): Blood levels and toxicity of these agents may increase. Salicylates: Uricosuric action of sulfinpyrazone may be reduced. Verapamil: Reduced efficacy of verapamil may occur.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Maintain adequate fluid intake and alkalinization of urine. Monitor I&O.
  • Monitor blood uric acid levels to evaluate efficacy of treatment.
  • Monitor complete blood cell counts for evidence of blood dyscrasias.
  • In patients with impaired renal function, monitor renal function test values.
  • Observe for upper GI disturbances, rash, or bronchoconstriction and report to physician.
OVERDOSAGE: SIGNS & SYMPTOMS
  Nausea, vomiting, diarrhea, epigastric pain, ataxia, labored respiration, convulsions, coma

Drug Storage/Management ::

 Administration/Storage

  • Administer with food or milk; add antacid if needed.

Drug Notes ::

 Patient/Family Education

  • Tell patient that medication is taken on daily basis to provide long-term protection from attacks of gout.
  • Point out that gout attacks may worsen during initial treatment but continue the drug.
  • Explain that other medications may be needed to control attacks of gout.
  • Explain that drug may cause GI distress and to take with food or milk and antacid if needed.
  • Instruct patient to report these symptoms to physician: rash, difficulty breathing, unusual bleeding or bruising, sore throat, fatigue or fever.
  • Explain importance of adequate hydration and instruct patient to drink 10 to 12 full glasses of fluid each day.
  • Advise patient to consult physician before using aspirin or other salicylates, acetaminophen or drinking alcohol.
  • Tell patient to notify physician if GI distress continues.

Disclaimer ::

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