The Brand Name ACUTROL-C Has Generic Salt :: SEVELAMER 

ACUTROL-C  Is From Company Intas Priced :: Rs. 209

ACUTROL-C have SEVELAMER is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Hyperphosphataemia

Drug Dose ::

Adult: PO: Patients not taking a Phosphate Binder: The recommended starting dose of Sevelamer is 800 to 1600 mg, which can be administered as two to four 400 mg Sevelamer tablets, with meals based on serum phosphorus level. Recommendation for the patients with hyperphosphatemia is given below- Table 1. Starting dose for dialysis patients not taking any phosphate binder. Serum Phosphorus————Sevelamer 400 mg > 5.5 and < 7.5 mg/dL ----2 tablets three times daily with meals 7.5 and < 9.0 mg/dL ----3 tablets three times daily with meals >9.0 mg/dL—————–4 tablets three times daily with meals Table 2. Starting dose for dialysis patients switching from calcium acetate to Sevelamer. Calcium Acetate 667 mg———- Sevelamer 400 mg (Tablets per meal)—————— (Tablets per meal) 1 tablet——————————–2 tablets 2 tablets——————————3 tablets 3 tablets———————–5 tablets Dose titration for all patients taking Sevelamer: Dosage should be adjusted based on the serum phosphorus concentration with a goal of lowering serum phosphorus to 5.5 mg/dl or less. The dose may be increased or decreased by one tablet per meal at two week intervals as necessary. Table 3. Dose titration guideline Serum Phosphorus ————-Sevelamer dose > 5.5 mg/dL ———————-Increase 1 tablet per meal at 2 week intervals 3.5 – 5.5 mg/dL ——————Maintain current dose < 3.5 mg/dL ----------------------Decrease 1 tablet per meal Contraindication ::

Hypophosphatemia or bowel obstruction.

Drug Precautions ::

Dysphagia, swallowing disorders, severe GI motility disorders, or major GI tract surgery. Pregnancy and lactation. Monitor serum levels of calcium, bicarbonate and chloride. To be taken with meals and tablets should be swallowed intact.

Drug Side Effects ::

Dyspepsia, peritonitis, diarrhea, nausea, constipation, pruritus, abdominal distension, vomiting, fatigue, anorexia, arthralgia and less commonly ileus, bowel obstruction and bowel perforation.

Pregnancy category ::

3

Drug Mode of Action ::  

Sevelamer, a polymeric compound, acts by binding to phosphate molecules in the gut, limiting its absorption and thus lowering serum phosphate levels w/o altering Ca, Al, or bicarbonate levels.

Drug Interactions ::

May decrease absorption of ciprofloxacin, ciclosporin, mycophenolate, tacrolimus and levothyroxine. Sevelamer should be given 3 hr before or 1 hr after taking other drugs to minimise potential pharmacokinetic interaction.