The Brand Name BIOSIM Has Generic Salt :: Simvastatin 

BIOSIM  Is From Company Biochem Priced :: Rs. 29.97

BIOSIM have Simvastatin is comes under Sub class Anti Hyperlipidemics of  Main Class Cardiovascular System

Main Medicine Class:: Cardiovascular System  Sub Medicine Class :: Anti Hyperlipidemics 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Simvastatin  TAB  Rs. 29.97  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 BIOSIM  Biochem  5MG  10 Rs. 29.97

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Biochem :: BIOSIM  Simvastatin  Cardiovascular System Anti Hyperlipidemics

Indications for Drugs ::

Hyperlipidaemias, stroke prevention

Drug Dose ::

Adult: PO Hyperlipidaemias Initial: 10-20 mg/day. May adjust dose at intervals of at least 4 wk. Max: 80 mg/day. CV risk reduction In high-risk patients: 20-40 mg once daily. Moderate-risk patients: 10 mg once daily.

Contraindication ::

Acute liver disease or unexplained persistent elevations of serum transaminases. Pregnancy, lactation. Porphyria. Patients of Chinese descent should not take 80 mg dose w/ lipid-modifying dose of niacin-containing products (?1 g/day).

Drug Precautions ::

History of liver disease. Increased risk of rhabdomyolysis in severe infection, hypotension, major surgical trauma, uncontrolled seizures or severe metabolic, endocrine and electrolyte disorder. Alcoholism; premenarcheal females; children <10 yr. Discontinue treatment if there is marked or persistent increase in serum-aminotransferase concentrations. Drug Side Effects ::

Headache, nausea, flatulence, heartburn, abdominal pain, diarrhoea/constipation, dysgeusia; dose-related myopathy (e.g. myalgia, muscle weakness and dark urine); serum transaminases and CPK elevations; hypersensitivity; lens opacities; blurring of vision; dizziness; sexual dysfunction; insomnia; depression and upper respiratory symptoms. Potentially Fatal: Severe rhabdomyolysis with acute renal failure.

Pregnancy category ::
Pregnancy category

5

Drug Mode of Action ::  

Simvastatin, an antilipemic agent is a competitive inhibitor of HMG-CoA reductase, the enzyme that catalyses the early and rate-limiting step in cholesterol biosynthesis reduces total cholesterol, LDL-cholesterol and triglycerides and increases HDL-cholesterol levels.

Drug Interactions ::

May increase bleeding risk w/ anticoagulants. Reduced serum levels w/ bosentan, efavirenz and rifampicin. Increased risk of myopathy and rhabdomyolysis w/ colchicine, amiodarone, verapamil and diltiazem. Increased risk of myopathy w/ amlodipine, fusidic acid. Potential reduction of cytotoxic effect of rituximab. Increased hepatotoxicity w/ ezetimibe. Potentially Fatal: Concurrent use w/ itraconazole, ketoconazole, posaconazole, clarithromycin, erythromycin, telithromycin, nefazodone, niacin, HIV protease inhibitors (e.g. nelfinavir), boceprivir, telaprevir, gemfibrozil, ciclosporin and danazol may increase the risk of myopathy, rhabdomyolysis and acute renal failure.

 

Disclaimer ::

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