Article Contents ::
Details About Generic Salt :: Candesartan
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Anti Hypertensives
| 4A. DRUGS FOR CARDIAC FAILURE & SHOCK in 4. CARDIOVASCULAR SYSTEM |
| CANDESARTAN |
| ANGIOTENSIN II RECEPTOR ANTAGONIST | ANTI-HYPERTENSIVE |
| also comes under 4D. Anti-Hypertensives in 4. Cardiovascular System, |
| PK: A: Rapid D: 0.13 L/kg (Vd) M: Intestinal wall E: Urine, Bile |
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Indications & Dose: HEART FAILURE PO Adult Initially 4mg OD, may double the dose at 2wk intervals, target dose 32mg/day Elderly Same as adult dose | HYPERTENSION PO Adult 16mg OD max 8-32mg/day Elderly Same as adult dose |
| Contra: Hypersensitivity, severe hepatic impairment, cholestasis, concurrent use of potassium-sparing diuretics
Precautions: Seizures, bipolar disorder/psychoses, history of CVD, hepatic/renal impairment, renal artery stenosis, volume depletion (high-dose diuretic therapy) ADR: Serious: Angina, hypotension, MI, tachycardia, angioedema, increased SeCr, dyspnea, renal failure, rhabdomyolysis, blood disorder, hematuria, abnormal hepatic function, Others: urticaria, back pain, CPK increased, URTI, increased diaphoresis, dizziness, light-headedness, drowsiness, headache, vertigo, anxiety, depression, somnolence, palpitation, fever, rash, hyperglycemia, hyperkalemia, hypertriglyceridemia, hyperuricemia, dyspepsia DDI: Serious Lithium toxicity occurs Diet: With/without food Monitor: Supine BP, electrolytes, Secr, BUN, urinalysis, symptomatic hypotension, serum K+ & tachycardia |