Article Contents ::
Details About Generic Salt :: Cisapride
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: GERD,
| 7A. GERD, ULCER/ANTACIDS in 7. GASTROINTESTINAL SYSTEM |
| CISAPRIDE |
| SUBSTITUTED BENZAMIDE | PROKINETIC DRUG |
| PK: A: Rapid M: Hepatic E: Urine, feces |
|
Indications & Dose: GASTROOESOPHAGEAL REFLUX DISEASE PO Adult 5-10mg TID-QID, max 40mg/day Child 200µg/kg TID-QID, max 800µg/kg Elderly half the usual doseassociated with decreased gastric motility & in non-ulcer dyspepsia |
| Contra: CYP450 potent inhibitors, drugs which prolongs QT interval or family history of QT interval prolongation, history of ventricular arrhythmia or torsade de pointes, renal failure, respiratory failure, infants <3 months after birth
Precautions: Renal/hepatic impairment, uncorrected electrolyte disturbances ADR: Serious: Hypersensitivity reactions, arrhythmia, ventricular tachycardia, ventricular fibrillation, torsade de pointes, QT interval prolongation, extrapyramidal effects, bronchospasm, convulsions, Others: increased urinary frequency, GI disturbances, abdominal cramps, diarrhea, headache & lightheadedness, rash, pruritus DDI: Serious Clarithromycin/Cimetidine/Diltiazem/Erythromycin/Ketoconazole/Nefazodone increases drug level leads to increase risk of QT prolongation & life-threatening ventricular arrhythmias, Ciclosporin level increased, Alcohol levels are modestly increased Diet: 15-30min before food & at bedtime Monitor: ECG, serum electrolytes & renal function before & during treatment |