Indications & Dose: HYPERTENSION PO Adult 50–100µg TID, increased every 2nd or 3rd day, max 1.2mg/day | IV Adult Inj: 150–300µg/day slowly, max 750µg/day | TD Adult A single patch releases 100-300µg/day at a constant rate is applied q1wk | MIGRAINE/OTHER VASCULAR HEADACHES Prophylactic therapy PO Adult 50µg BID, increased to 75µg BID if there is no remission after 2 wk

Precautions: Cerebrovascular disease, CNS depressants, agents with blocking properties of SA/AV node, withdraw gradually, renal impairment, IV inj should be given slowly, history of depression, ischemic heart disease including MI, occlusive peripheral vascular disorders

ADR: Serious: Sinus bradycardia with AV block, Raynaud’s syndrome, gynecomastia, HF, Others: drowsiness, depression, dizziness, nervousness, nightmares, constipation, dry mouth, urinary retention, nocturia, pruritus, dermatitis, weight gain

DDI: Serious Propofol attenuates responses to hypercapnia by drug, ACEIs causes potentiation of antihypertensive efficacy, Phenothiazines/Haloperidol increases hypotension & orthostasis, CNS Depressants/Alcohol increases sedation, β-blockers leads to rebound hypertension for the sudden withdrawal of drug, Prazosin reduces antihypertensive effects of drug, TCAs reduces/abolishes antihypertensive effects of drug, Antidiabetics suppress signs & symptoms of hypoglycaemia

Diet: With/without food

Monitor: BP, mental status, HR, catheter-related infect