Article Contents ::
Details About Generic Salt :: Diphenoxylate
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: Anti Diarrheal
| 7B. ANTI-DIARRHEAL in 7. GASTROINTESTINAL SYSTEM |
| DIPHENOXYLATE |
| OPIOID AGONIST | ANTI-DIARRHEAL |
| PK: A: Well absorbed M: Liver E: Feces |
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Indications & Dose: DIARRHEA PO Adult Initially 10mg, followed by 5mg q6h, then reduce as control is achieved, may increase to max 20mg/day in chronic conditions. Diphenoxylate usually given with subclinical doses of atropine in an attempt to discourage abuse |
| Contra: Patients with jaundice, intestinal obstruction, antibiotic associated colitis, diarrhea associated with enterotoxin-producing bacteria, infants
Precautions: Hepatic impairment, young children, patients with IBD ADR: Serious: Paralytic ileus, toxic megacolon, pancreatitis, hypersensitivity reactions, Others: Anorexia, nausea, vomiting, abdominal distension/discomfort, headache, drowsiness, dizziness, restlessness, euphoria, depression, numbness of the extremities |