Article Contents ::
Details About Generic Salt :: Domperidone
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: Anti Emetics
| 1H. ANTI-MIGRAINE & ANTI- VERTIGO DRUGS in 1. NERVOUS SYSTEM |
| DOMPERIDONE |
| DOPAMINE ANTAGONIST | PROKINETIC, GI STIMULANT |
| also comes under 7D. Anti-Emetics in 7. Gastrointestinal System, |
| PK: A: Rapid M: Hepatic E: Feces, urine |
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Indications & Dose: GASTROINTESTINAL MOTILITY DISORDER PO Adult 10mg TID/QID | MIGRAINE Combination therapy PO Adult 20mg q4h, with paracetamol, as required, up to a max of 4 doses in 24h | NAUSEA/VOMITING PO Adult 10-20mg TID/QID, max 80mg Child 250-500µg/kg TID/QID, max 2.4mg/kg total daily dose or 80mg, whichever is less | RECTAL Adult 60mg BID Child >15 kg: 30mg BID | NON-ULCER DYSPEPSIA Symptomatic therapy PO Adult 10mg QID (the last dose at night) increased to 20mg if required, 2-4 wk |
| Contra: Hypersensitivity, GI hemorrhage, mechanical obstruction/perforation, patients with prolactin releasing pituitary tumor, concomitant use with ketoconazole
Precautions: Severe renal impairment, hepatic impairment, history of breast cancer, patients on MAO inhibitors ADR: Serious: Convulsions, cardiac arrest, arrhythmias, gynaecomastia/galactorrhoea, Others: Reduced libido, rashes, allergic reactions, extrapyramidal reactions, dystonic reactions, drowsiness, headache, xerostomia DDI: Serious Bromocriptine hypotensive effect is reduced, Ketoconazole/Erythromycin increases drug levels, Paracetamol rate of absorption increases by drug Monitor: Renal function |