Article Contents ::
Details About Generic Salt :: Doxazosin
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Anti Hypertensives
| 10C. DRUGS FOR PROSTATE DISORDERS in 10. GENITO-URINARY SYSTEM |
| DOXAZOSIN |
| SYMPATHOLYTIC, PERIPHERALLY ACTING ANTIADRENERGIC | ANTI-HYPERTENSIVE |
| also comes under 4D. Anti-Hypertensives in 4. Cardiovascular System, |
| PK: A: Well absorbed M: Hepatic E: Feces, urine |
|
Indications & Dose: BENIGN PROSTATIC HYPERPLASIA PO Adult IR: 4-8mg/day, max 8mg/day; ER: 4mg OD, titrate based on response & tolerability q3-4 wk, max 8mg/day | HYPERTENSION PO Adult 1mg OD, may be increases to 2mg, thereafter titrate upwards, max 16mg/day. If therapy is discontinued for several days, restart at 1mg & titrate as before |
| Contra: Hypersensitivity, HF
Precautions: Renal/hepatic impairment, angina, increased GI obstruction, elderly ADR: Serious: Arrhythmias, orthostatic hypotension, hypotension, edema, palpitation, syncope, flushing, conjunctivitis, blurred vision, arthritis, myalgia, gout, Others: Dizziness, vertigo, headache, depression, drowsiness, fatigue, nervousness, weakness, rhinitis, pharyngitis, nausea, vomiting, diarrhea, flatulence, dry mouth, decreased libido, sexual dysfunction, dyspnea DDI: Serious Diuretics/ACEIs results in an additive hypotensive effect, Tadalafil/Sildenafil/Vardenafil results in postural hypotension Diet: With food Monitor: BP, standing & sitting/supine, syncope |
