Article Contents ::
Details About Generic Salt :: Ezetimibe
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Fluid , Electrolyte Preparations
| 4F. ANTI-HYPERLIPIDEMICS in 4. CARDIOVASCULAR SYSTEM |
| EZETIMIBE |
| CHOLESTEROL ABSORPTION INHIBITOR | ANTI-HYPERLIPIDEMIC |
| PK: A: Rapid M: Small intestine & hepatic E: Feces, urine |
|
Indications & Dose: HOMOZYGOUS SITOSTEROLEMIA PO Adult 10mg/day Child =>10 yr: Same as adult dose Elderly Same as adult dose | PRIMARY HYPERCHOLESTEROLEMIA PO Adult 10mg/day Child =>10 yr: Same as adult dose Elderly Same as adult dose |
| Contra: Hypersensitivity, concomitant use with an HMG-CoA reductase inhibitor, moderate-to-severe hepatic impairment, children <10yrs
Precautions: Mild hepatic impairment, severe renal impairment (Clcr <30 mL/min) ADR: Serious: Angioedema, arthralgia, hepatitis, pancreatitis, myalgia, cholelithiasis, thrombocytopenia, Others: Headache, abdominal pain, diarrhea, GI disorders, hypersensitivity reactions, rash, fatigue, chest pain DDI: Serious Rifampicin abolishes drug levels, Fenofibrate/Ciclosporin/Gemfibrozil increases drug levels, Colestyramine reduces drug exposure Diet: With/without food Monitor: Lipid profile, LFT & signs & symptoms of cholelithiasis |