The Brand Name FLEXITAL Has Generic Salt :: Pentoxifylline 

FLEXITAL  Is From Company Sun Priced :: Rs. 23.5

FLEXITAL have Pentoxifylline is comes under Sub class Drugs for Vascular disorder of  Main Class Cardiovascular System

Main Medicine Class:: Cardiovascular System  Sub Medicine Class :: Drugs for Vascular disorder 

Indications for Drugs ::

Peripheral vascular disease

Drug Dose ::

Adult: PO Extended release 400 mg 3 times/day (normally for at least 8 wk), may reduce to 400 mg twice daily if adverse effects occur.

Contraindication ::

Previous hypersensitivity reactions to xanthine-related products e.g. caffeine, theophylline and theobromine. Recent cerebral and/or retinal haemorrhage. Porphyria.

Drug Precautions ::

Avoid use in patients with severe cardiac arrhythmias or acute MI. Caution when used in patients with ischaemic heart disease or hypotension. Impaired renal or hepatic function. Start at lower dose in elderly; safety and efficacy not established in children. Tablets should not be chewed, crushed or broken; swallow whole. Pregnancy, lactation.

Drug Side Effects ::

Nausea, vomiting, dizziness, headache, flushing; angina, palpitations; occasional cardiac arrhythmias; hepatitis, jaundice; blood dyscrasias reported; agitation; sleep disturbances; hypotension; thrombocytopenia; intrahepatic cholestasis. Potentially Fatal: Fatal haemorrhage (cerebral and GI tract); anaphylactoid reaction.

Pregnancy category ::

3

Drug Mode of Action ::  

Pentoxifylline reduces blood viscosity by increasing deformability of leukocytes and erythrocytes; and decreasing neutrophil adhesion/activation. It also improves microcirculation and peripheral tissue oxygenation through better blood flow. It has also been used in cerebrovascular disorders.

Drug Interactions ::

Concurrent use with ciprofloxacin may increase the adverse effect of pentoxifylline. Concurrent use may increase serum levels of theophylline derivatives. Potentially Fatal: May increase risk of adverse effect when used with ketorolac.