Article Contents ::
Details About Generic Salt :: Pantoprazole
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: GERD,
| 7A. GERD, ULCER/ANTACIDS in 7. GASTROINTESTINAL SYSTEM |
| PANTOPRAZOLE |
| PPI | ANTI-ULCER |
| PK: A: Well absorbed D: 11-24 L (Vd) M: Hepatic E: Urine (71%), feces (18%) |
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Indications & Dose: BENIGN GASTRIC/DUODENAL ULCER PO Adult 40mg OD 4-8 wks | EROSIVE ESOPHAGITIS ASSOCIATED WITH GERD PO Adult 40mg OD 8 wks, continue further 8 wks if ulcer is not healed, MD 40mg OD 40mg OD 8 wks, continue further 8 wks if ulcer is not healed, MD 40mg OD | IV Adult 40mg OD 7-10 days | GASTROESOPHAGEAL REFLUX DISEASE Mild PO Adult 20mg OD | H.PYLORI INFECT PO Adult 40mg OD 2-4 wks | PO Adult Pantoprazole 40mg BID with clarithromycin 500mg BID & amoxicillin 1g BID, or with clarithromycin 250mg BID & metronidazole 400mg BID | HYPERSECRETORY DISORDERS IV Adult 60-240mg/day in divided doses 7 days | NSAID-INDUCED GASTRIC ULCERS PO Adult 20mg/day | ZOLLINGER-ELLISON SYNDROME PO Adult Initially 40mg BID, max 240mg/day | IV Adult 60-240mg/day in divided doses 7 days |
| Contra: Hypersensitivity
Precautions: Hepatic impairment, children ADR: Others: Dizziness, headache, rhinitis, vomiting, diarrhea, abdominal pain, dyspepsia, hyperglycemia, rash, pruritus, flu syndrome DDI: Serious Digoxin/Clozapine levels increased, Methotrexate levels increases & leads to myalgia, Cisapride levels reduced Diet: Before food(morning) Monitor: Acid output measurements, blood glucose level |