The Brand Name PRADIL Has Generic Salt :: PROPAFENONE 

PRADIL  Is From Company Emcure Priced :: Rs. 161.16

PRADIL have PROPAFENONE is comes under Sub class Anti Arrhythmics of  Main Class Cardiovascular System

Main Medicine Class:: Cardiovascular System  Sub Medicine Class :: Anti Arrhythmics 

Indications for Drugs ::

Supraventricular and ventricular arrhythmias

Drug Dose ::

Oral Supraventricular and ventricular arrhythmias Adult: Doses should be started under close monitoring of ECG and BP. For immediate-release tablet: Usual initial doses: 150 mg tid, may increase at intervals of 3-4 days up to 300 mg tid. Dose reduction is recommended in patients weighing <70 kg. For extended-release capsule: Initial doses: 225 mg every 12 hr; may increase dose at intervals of at least 5 days, up to 325-425 mg every 12 hr Elderly: Dose reduction is recommended. Hepatic impairment: Dose reduction is recommended. Special Populations: Reduce dose in elderly, patients weighing <70 kg and in those with hepatic impairment. Contraindication ::

Uncontrolled heart failure, marked hypotension, severe bradycardia and heart block, conduction abnormalities, cardiogenic shock, myasthenia gravis.

Drug Precautions ::

Severe pulmonary obstructive diseases, CHF, cardiac pacemaker, impaired renal/hepatic function, pregnancy, lactation, elderly. Correct electrolyte disturbances before starting treatment. May worsen heart failure in patients with preexisting organic heart disease. May worsen or cause new severe ventricular arrhythmias e.g. ventricular tachycardia or fibrillation. May aggravate electrically induced ventricular tachycardia in some patients.

Drug Side Effects ::

Dizziness, headache, visual disturbances, vertigo, dry mouth, GI disturbances, alteration in taste, allergic skin rashes, leucopenia, bradycardia and bitter or metallic taste. Potentially Fatal: SA/AV or intraventricular blocks. Severe hypotension, especially in elderly.

Pregnancy category ::

3

Drug Mode of Action ::  

Propafenone is a class 1C antiarrhythmic drug with local anaesthetic effects, and a direct stabilising action on myocardial membranes. The electrophysiological effect manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity.

Drug Interactions ::

Effect may be potentiated by local anesth, ?-blockers, TCA. May increase plasma level of propranolol, metoprolol, desipramine, cyclosporin, digoxin, theophylline. Plasma conc may rise when taken simultaneously w/ cimetidine or quinidine. May enhance effect of anticoagulant. Simultaneous administration w/ phenobarb or rifamycin may decrease propafenone plasma conc, possibly in sub-therapeutic levels.