Indications & Dose: PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA IV Child Loading dose 2-6mg/kg administered over 5 min, repeat at intervals of 5-10 min, if needed, max loading dose 15mg/kg or 500mg in 30 min | SUPRAVENTRICULAR TACHYCARDIA PO Adult Initially 1.25g, if no response 750mg after 1h, additional dosage of 0.5-1g q2h until normal sinus rhythm restores/toxic effects appear Child 15-50mg/kg/day, max 4g/day | IM Adult Initially 50mg/kg in divided doses (q3-6h) | VENTRICULAR ARRHYTHMIAS PO Adult Up to 50mg/kg/day in divided doses q3h MD 50mg/kg/day in equally divided doses q6h Child 15-50mg/kg/day in divided doses max 4g/day | IV Child Loading dose 2-6mg/kg administered over 5 min, repeat at intervals of 5-10 min, if needed, max loading dose 15mg/kg or 500mg in 30 min | IM Adult 50mg/kg/day in divided doses q3h followed by PO MD 50mg/kg/day in equally divided doses q6h | IM Adult Initially 50mg/kg in divided doses q3-6h; Arrhythmias occur during surgery/anesthesia 100-500mg | VENTRICULAR PREMATURE COMPLEX PO Adult 6.25mg/kg q3h

Precautions: Renal impairment, antiarrhythmics, elderly, myocardial damage/severe organic heart disease

ADR: Serious: Fatal blood dyscrasias, hypotension, positive ANA, SLE, hepatomegaly, bone marrow suppression, flushing, ventricular fibrillation, respiratory failure, angioedema, Others: depression, dizziness, arthralgia, fever, rash, diarrhea, nausea, vomiting

DDI: Serious Pyridostigmine causes serious aggravation of myasthenic symptoms, Amiodarone increases QT interval prolonging effects, Trimethoprim/Cimetidine increases serum drug levels, Lidocaine leads to delirium, Quinidine markedly increases drug levels, Quinolones moderately increases serum drug levels

Monitor: ECG, BP, renal function