Indications & Dose: BRONCHIOLITIS Inh Child 1 month–2 yr: 20mg/mL 12–18h at least 3 days, max 1 wk | HEPATITIS C Chronic Combination therapy PO Adult 65–86 kg: 400mg morning & 600mg HS, 86–105 kg: 600mg BID, >105 kg: 600mg morning & 800mg HS with Interferon alfa/peginterferon alfa Child <47 kg: 15mg/kg/day in 2 divided doses, 47–50 kg: 200mg morning & 400mg HS, 50–65 kg: 400mg BID with Interferon alfa/peginterferon alfa | RESPIRATORY SYNCYTIAL VIRUS INFECT IV Child 33mg/kg single dose, then 16 mg/kg every 6 hours for , then 16mg/kg q6h 4days followed by 8mg/kg q8h 3days (immunocompromised)

Precautions: hemolytic anemia, hepatic/renal impairment, COPD, pancreatitis, psychiatric disorders, pulmonary disorders, autoimmune/infectious disorders, elderly, children, CVD

ADR: Serious: BP fall, bacterial pneumonia, pneumothorax, conjunctivitis, reticulocytosis, cardiac arrest, increased bilirubin, suicidal ideation, growth retardation, hemolytic anemia, auto-immune disorders, DM, pulmonary embolism, severe depression, bacterial infect, Others: taste perversion, blurred vision, dyspnea, aggression, menstrual disorder, skin rashes, dyspepsia, diaphoresis, alopecia, anorexia, pharyngitis, headache

DDI: Serious Didanosine causes risk of lactic acidosis, blood dyscrasias & hepatotoxicity, NRTIs increases risk of hepatotoxicity, blood dyscrasias, Zidovudine leads to severe neutropenia & anaemia

Diet: With food

Monitor: Inhalation: Respiratory function, hemoglobin,reticulocyte count,CBC; Oral: CBC, TSH, platelet count, serum HCV RNA, CD4+ cell count,dental exams,ECG changes, growth before & after treatment