Article Contents ::
Details About Generic Salt :: Irbesartan
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Anti Hypertensives
| 4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM |
| IRBESARTAN |
| ANGIOTENSIN II RECEPTOR ANTAGONIST | ANTI-HYPERTENSIVE |
| PK: A: Rapid D: 53-93 L (Vd) M: Hepatic E: Feces (80%), urine (20%) |
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Indications & Dose: DIABETIC NEPHROPATHY PO Adult 300mg/day | HYPERTENSION PO Adult 150mg/day, max 300mg/day Child >6-12 yr: 75mg/day, max 150mg/day, >13 yr: Same as adult dose | HYPERTENSIVE NEPHROPATHY PO Adult 300mg/day |
| Contra: Hypersensitivity
Precautions: Hypovolemia, aortic/mitral stenosis, unilateral/bilateral renal artery stenosis, renal impairment, elderly ADR: Serious: Orthostatic hypotension, renal failure, hyperkalemia, myalgia, Others: GI disturbances, fatigue, neutropenia, rash, urticaria, URTI, diarrhea, dyspepsia, fatigue, dizziness DDI: Serious Aliskiren leads to greater reduction in BP, Lithium leads to lithium toxicity, Antacids reduces drug levels, Fluconazole reduces drug metabolism Diet: With/without food |