Article Contents ::
Details About Generic Salt :: Acenocoumarol
Main Medicine Class:: Hematological System Sub Medicine Class :: Anti Coagulants
| 5B. ANTI-COAGULANTS in 5. HEMATOLOGICAL SYSTEM |
| ACENOCOUMAROL |
| VITAMIN K ANTAGONIST | ANTI-COAGULANT |
| PK: A: 60% M: Liver E: Urine(60%)& feces(29%) as metabolites |
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Indications & Dose: THROMBOEMBOLIC DISORDERS PO Adult Day 1: 4-12mg, Day 2: 4-8mg MD 1-8mg based on responseAcenocoumarol is given in a single dose at the same time every day |
| Contra: serious hemorrhage risk, PUD, severe HTN, severe renal/hhepatic impairment, cerebrovascular disorders, bacterial endocarditis, bleeding, blood disorders, surgery, major regional lumbar block anesthesia, CV hemorrhage, aneurysm, eclampsia/pre-eclampsia, malnutrition, diverticulitis/ prostatectomy, vit k/ ascorbic acid deficiency, alcoholics, patient with history of falls
Precautions: recent surgery, polypharmacy, moderate-to-severe HTN, anaphylactic disorders, severe DM, trauma, acute infect, skin necrosis/gangrene, vasculitis, open wound, accidents/falls, thyroid disease, menstruating/postpartum women, active TB, indwelling catheters, protein C deficiency, purple toe syndrome, elderly, polycythemia vera ADR: Serious: hypersensitivity/allergic reactions, hemorrhage, stroke, urticaria, skin necrosis, GI bleeding, hematuria, retroperitoneal hematoma, blood disorders, hepatitis/hepatotoxicity, Others: rash, fever, headache DDI: Serious Fibrates causes severe bleeding, HIV protease inhibitors decreases drug effects, Fluconazole/Amiodarone/Miconazole increases anticoagulant effect, Piroxicam increases drug plasma levels, NSAIDs leads to GI hemorrhage, Clindamycin leads to increases bleeding & INR, Vancomycin/Cotrimoxazole leads to over anticoagulation, Mercaptopurine/Aminoglutethimide/Rifampicin reduces anticoagulant effect Diet: Avoid Vit K rich food Monitor: PT/INR, LFT, CBC & urine analysis |