Post Contents List
- 1 ACTH DEFICIENCY
- 2 ACTH SYNTHESIS —
- 3 Adrenal insufficiency secondary to ACTH deficiency is due to :
- 4 ACTH DEFICIENCY Lab diagnosis:
- 5 CONTROL OF ACTH SECRETION —
- 6 TSH DEFICIENCY
- 7 Major symptomsAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... » and signsAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... » of hypothyroidismThyroid Disorders Examination and Laboratory tests. Read more ... » –
- 8 Hypothalamic hypothyroidism:
- 9 Treatment:
ACTH DEFICIENCY
ACTH SYNTHESIS —
- POMC also contains the sequences for other hormonal peptides, including the melanocyte-stimulating hormones (MSHs) lipotropins (LPHs), and beta-endorphin (beta-END)
- ACTH is synthesized as part of a large precursor (241 amino acids in humans) called proopiomelanocortin (POMC).
ACTH and TSH DEFICIENCY DiagnosisAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... » with TreatmentAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... »
Adrenal insufficiency secondary to ACTH deficiency is due to :
- · glucocorticoid withdrawal after long treatment
- · surgical resection of pituitaryAldosteronism Clinical features Causes and Treatment. Read more ... » adenoma
- · pituitary adenomasHypothalamic, Pituitary And Other Sellar Masses. Read more ... » or other masses due to compression effect
- There is fatigueFatigue diagnosis medicine and treatment. Read more ... », weakness, anorexia, nauseaNausea and Vomiting. Read more ... », vomiting, hypoglycemia.
- There are no pigmentation changes or mineralocorticoid deficiency which is a feature of primary adrenalAldosteronism Clinical features Causes and Treatment. Read more ... » failure.
ACTH DEFICIENCY Lab diagnosis:
- low ACTH levels with low cortisol levels.
- On giving ACTH stimulation, there is no cortisol response.
CONTROL OF ACTH SECRETION —
- ACTH secretion is regulated by multiple hormones.
- CRH is probably the most important ACTH secretagogue .
- Beta-END has potent opioid activity in the central nervous systemAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... », but its function in peripheral plasma is unknown
- AVPSIADH or Syndrome of inappropriate ADH (AVP). Read more ... » alone is a weak stimulator of ACTH secretion, but it potentiates the action of CRH in vivo and in vitro
TSH DEFICIENCY
Major symptomsAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... » and signsAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... » of hypothyroidismThyroid Disorders Examination and Laboratory tests. Read more ... » –
| TSH DEFICIENCY Mechanism | TSH DEFICIENCY Symptoms | TSH DEFICIENCY Signs |
| Slowing ofmetabolic processes | Weight gainMental retardation (infant)
Growth failure Fatigue and weakness Dyspnea on exertion Constipation Cold intolerance Cognitive dysfunction |
BradycardiaCarotenemia
Delayed relaxation of tendon reflexes Slow movement and slow speech |
| Accumulation ofmatrix substances | Dry skinEdema
Hoarseness |
Coarse skinEnlargement of the tongue
Periorbital edema Puffy facies and loss of eyebrows |
| Other | ArthralgiaDecreased hearing
DepressionVisada Depression Ayurveda and Modern. Read more ... » Menorrhagia Myalgia and paresthesia Pubertal delay |
AscitesDiastolic hypertensionHypertension Definition Classification. Read more ... »
Galactorrhea Pleural and pericardial effusions |
- Pituitary hypothyroidism is characterized by low TSH level with low free thyroidThyrotoxic crisis or Thyroid storm. Read more ... » hormoneAnterior Pituitary Hormones and Disorders. Read more ... ».
Hypothalamic hypothyroidism:
- Patients with hypothyroidismThyroid Disorders Examination and Laboratory tests. Read more ... » of hypothalamicHypothalamic, Pituitary And Other Sellar Masses. Read more ... » origin will have decreased TRH and slightly increased TSH levels.
- TRH 200 IJg IV causesAmoebiasis infection Diagnosis Treatment protozoan Entamoeba histolytica Symptoms and Causes. Read more ... » a double increase in TSH levels in half an hour.
Treatment:
- Thyroid replacement therapy.
- Levothyroxine (Synthroid, Levothroid): 1.6 mcg/kg/d; increase by 25 mcg/d every 4–6 weeks until TSH in normal range