Post Contents List
- 1 Acute Respiratory Distress Syndrome ARDS
- 2 Criteria of ARDS
- 3 All criteria
- 4 ARDS criteria
- 5 Predisposing factors
- 6 Risk Factorsfor Acute Respiratory Distress Syndrome (ARDS)
- 7 Clinical feature of ARDS
- 8 Physical Exam in ARDS
- 9 X-ray:
- 10 Pathophysiology of Acute Respiratory Distress Syndrome (ARDS)
- 11 Causes of Acute Respiratory Distress Syndrome (ARDS)
- 12 Treatment of Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome ARDS
- There is lung injury manifested as increased permeability of alveolar capillary membrane, diffuse alveolar damage, proteinaceous pulmonary edemaPulmonary Edema Causes Diagnosis with Treatment. Read more ... ».
- Age: ARDS or AcuteHypertension with Diabetes, heart failure, MI, CHF and Hypertension with Pregnancy. Read more ... » Respiratory Distress SyndromeMetabolic,Insulin Resistance Syndrome X Causes Symptoms. Read more ... » may occur in children or adults.
- Syndrome characterized by abrupt onset of diffuse lung injury with severe hypoxemia and bilateral pulmonary infiltratesEosinophilic pneumonias PULMONARY INFILTRATES WITH EOSINOPHILIA. Read more ... »
- Absence of left atrial hypertensiom (HTN)
- By consensus, PaO2/FiO2 <200
- Most severe form of acute lung injury
- SystemHypertension with Diabetes, heart failure, MI, CHF and Hypertension with Pregnancy. Read more ... »(s) affected: Pulmonary; Cardiovascular
- Synonym(s): ShockShock Presentation Risk Factors Pathogenesis Management Treatment. Read more ... » lung; Wet lung; Noncardiac pulmonary edema
- Acute respiratory distress syndrome (ARDS) develops rapidly and includes severe dyspnea and hypoxemia;
- it typically causesHypertension with Diabetes, heart failure, MI, CHF and Hypertension with Pregnancy. Read more ... » respiratory failureRespiratory Failure Causes Clinical Features with Management. Read more ... ».
- Key diagnostic criteria for ARDS include diffuse bilateral pulmonary infiltrates on chest x-ray (CXR); PaO2 (arterial partial pressureChronic Long-term Complications Of Diabetes Mellitus. Read more ... » of oxygen in mmHg)
Criteria of ARDS
- Severe hypoxemia
- Decreased pulmonary compliance
- Diffuse pulmonary infiltrates on chest X-ray.
- It is a form of noncardiogenic pulmonary edema. Acute Lung Injury (ALI) is a less severe form of ARDS.
- Acute onset
- PaO2/FI02 < 300mg Hg
- Chest X-ray – Bilateral infiltrates.
- PAP –< 18 mmHg (Pulmonary artery pressure is less than 18mmHg).
- No clinical evidence of left atrial hypertensionDiabetes Insipidus (DI) Causes Diagnosis and Treatment. Read more ... ».
- Acute onset
- PaO2/FI02 < 200mg Hg
- Bilateral infiltrates.
- PCWP ~ 18 mmHg (Pulmonary capillary wedge pressure is less than 18mmHg).
- No clinical evidence of increased LA pressure.
- Severe sepsisSepsis (Septic Shock) Definition Diagnosis and Pathophysiology. Read more ... », trauma, aspiration of gastric contents. 40% of these will develop ARDS.
- A H/O chronicChronic Hepatitis Classification viral hepatitis Clinical features and Treatment. Read more ... » alcohol abuse increases risk of ARDS.
- ARDS occurs within 5 days of the precipitating event.
- 50% develop within 1 day.
- Severe infection (localized or systemic ) most common
- Aspiration of gastric contents
- Lung contusion
- Nonthoracic trauma
- Toxic inhalation
- Near drowning
- Multiple blood transfusions
Clinical feature of ARDS
- There is : Increased respiratory rate
- In sepsis there is increased ne.
- In pancreatitis, there is increased serum amylase level.
Physical Exam in ARDS
- Flat neck veins
- Hyperdynamic pulses
- Physiologic gallop
- Absence of edema
- Tachypnea and tachycardiaHyperglycemic Hyperosmolar State (HHS) Acute Complication Of DM. Read more ... » during the 1st 12– 24 h; respiratory distress
- Lethargy, obtundation
- Moist, cyanotic skin: Manifestations of underlying diseaseHypertension with Diabetes, heart failure, MI, CHF and Hypertension with Pregnancy. Read more ... »
- diffuse infiltrates with heterogenous pattern – more in dependent lung.
Pathophysiology of Acute Respiratory Distress Syndrome (ARDS)
- 3 phases:
- Acute exudative phase: Characterized by profound hypoxia and associated with inflammation with infiltration of inflammatory and proinflammatory mediators and diffuse alveolar damage
- Fibrosing alveolitis phase: Coincides with recovery or after ~1–2 weeks; patients continue to be hypoxic and have increased dead space and decreased compliance.
- Resolution may require 6–12 months.
- Heightened inflammatory response Initiation
Causes of Acute Respiratory Distress Syndrome (ARDS)
- Aspiration of gastric contents -
- Contusion to lungs
- Toxin inhalation
- Sepsis syndrome
- Non-thoracic trauma
- There is mediator and cytokine-release like TNF alpha interleukin-
- 1. Neutrophils cause acceleration of rseponse
- Release of oxygen, metabolites and proteases causes injury leading to MODS (Multiple Organ Dysfunction, Syndrome).
- Pulmonary edema
- Bronchial wall edema
- Narrowing of bronchi leading to :
- High pulmonary vascular resistance
- High pulmonary arteriolar pressure due to
- release of thromboxane A2 and leukotrines.
- There may be recovery or chronic pulmonary disease. Chronic changes in lung often leads to death.
Treatment of Acute Respiratory Distress Syndrome (ARDS)
- No single drugHypertension with Diabetes, heart failure, MI, CHF and Hypertension with Pregnancy. Read more ... » or combination of drugs prevents or treats full-blown ARDS. Treatment is supportive while addressing the underlying cause.
- Supplemental oxygen
- Ventilatory support most often requires endotracheal intubation with emphasis on lower tidal volumes per weight and optimization of positive end-expiratory pressure (PEEP).
- 02 inhalation is not effective.
- Mechanical ventilation should be instituted. Mechanical ventilation can lead to 02 toxicity, barotrauma, pneumothoraxPneumothorax Symptoms Causes Diagnosis Treatment with emergency. Read more ... », pneumo-mediastinum, SIC emphysemaChronic Obstructive Pulmonary Disease (COPD) Clinical features Symptoms Diagnosis. Read more ... ».
- Tidal volume of 10 ml/Kg can lead to barotrauma. Maximum inflation pressure < 35cm H20.
- Tidal volume should be <6 ml/kg.
- FI02 is kept < .6
- Pa02 maintained at 60 mmHg.
- PEEP added 5 cm H20 up to 20 cm H20. Restriction of fluids.
- Inotropic agents: Dobutamine to maintain adequate cardiacCHRONIC CONSTRICTIVE PERICARDITIS Physical findings and Treatment. Read more ... » output after appropriate fluid resuscitation fails to restore perfusion
- Deep vein thrombosis (DVT) prophylaxis
- Ulcer prophylaxis
- Inhaled B2 agonists may be helpful during the resolution phase.
- Maintain lowest possible intravascular hydrostatic pressure.
- Hypercapnia, respiratory acidosisAcidosis & Alkalosis physiology with signs and symptoms. Read more ... » occurs with mechanical ventilation called permissive hypercapnia.
- Steroids may be given. Give surfactants, nitric oxide inhalation to reduce pulmonary arterial pressure.
- Mortality 50% to 70% Early mortality <3 days Late mortality >3 days