The Brand Name AQUAZIDE Has Generic Salt :: Hydrochlorothiazide
AQUAZIDE Is From Company Sun Priced :: Rs. 11
AQUAZIDE have Hydrochlorothiazide is comes under Sub class Diuretics of Main Class Genito Urinary System
Main Medicine Class:: Genito Urinary System Sub Medicine Class :: Diuretics
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Indications for Drugs ::
Hypertension, Congestive heart failure, Oedema, Diabetes insipidus, Renal tubular acidosis
Drug Dose ::
Oral Hypertension Adult: Initially, 12.5 mg, may increase to 25-50 mg once daily as necessary either alone or w/ other antihypertensives. Child: <6>2-12 yr 1-2 mg/kg/day in 1-2 divided doses Max: 100 mg daily. Elderly: 12.5-25 mg once daily, titrate as necessary in increments of 12.5 mg. Oedema associated w/ heart failure Usual: 25-100 mg/day in the morning, may reduce based on response. Severe: Up to 200 mg/day. Child: <6>2-12 yr 1-2 mg/kg/day in 1-2 divided doses Max: 100 mg daily. Elderly: 12.5-25 mg once daily, titrate as necessary in increments of 12.5 mg. Nephrogenic diabetes insipidus Initial: Up to 100 mg/day.
Severe hepatic and renal impairment, Addison’s disease, preexisting hypercalcaemia, anuria, sulphonamide allergy. Pregnancy, lactation.
Drug Precautions ::
Existing electrolyte disturbances, hepatic cirrhosis, severe heart failure, oedema, elderly, renal impairment. Monitor for signs of fluid and electrolyte disturbance. Hepatic impairment, DM, gout, hyperlipidaemia, hypercalcaemia, hyperuricaemia; ECG: LVH and/or ventricular ectopics (extrasystoles). May exacerbate or activate SLE in susceptible patients.
Drug Side Effects ::
Volume depletion and electrolyte imbalance, dry mouth, thirst, lethargy, drowsiness, muscle pain and cramps, hypotension, hypersensitivity reactions e.g. rashes, photosensitivity, thrombocytopenia, jaundice, pancreatitis; fatigue, weakness; may precipitate an attack of gout; impotence, hyperglycaemia; anorexia, gastric irritation, nausea, vomiting, constipation, diarrhoea, sialadenitis, dizziness, raised Ca concentration. Potentially Fatal: Hypersensitivity reactions.
Pregnancy category ::
Drug Mode of Action ::
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Drug Interactions ::
Increases toxicity of lithium. May potentiate orthostatic hypotension w/ barbiturates and narcotics. Enhanced neuromuscular blocking action of competitive neuromuscular blockers (e.g. atracurium). Increased hypokalaemic effect w/ corticosteroids, corticotropin, ?2 agonists (e.g. salbutamol). Additive effect w/ other antihypertensives. Potentiation of orthostatic hypotension w/ barbiturates or opioids. Reduced antihypertensive effect by drugs that cause fluid retention (e.g. corticosteroids, NSAIDs, carbenoxolone). Enhanced nephrotoxicity of NSAIDs. Reduced therapeutic effect of antidiabetics.