Asparaginase

Details About Generic Salt ::  Asparaginase 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
ASPARAGINASE
ENZYME | ANTI-NEOPLASTIC
PK: D: 4-5L/kg (Vd) E: Little

Indications & Dose: ACUTE LYMPHOBLASTIC LEUKEMIA Mono therapy IV Adult Induction of remission: 1000U/kg/day for 10 days after treatment with vincristine, prednisone/prednisoloneAdministered with 0.9% NaCl/ 5% dextrose for 30 min | IM Adult Induction of remission: 6000U/m2 qthird day for 9 doses during treatment with vincristine, prednisone/prednisolone2ml should be given at one site

Contra: Hypersensitivity, pancreatitis, thrombosis, serious hemorrhage

Precautions: Bone marrow depression, CNS depression, renal/hepatic disease

ADR: Serious: anaphylaxis, hypersensitivity, bronchospasm, seizures, hyperuricemia, ketoacidosis, hypoalbuminemia, hyperammonemia, renal failure, leucopenia, Parkinson like syndrome, Others: nausea, vomiting, CNS disturbances, drowsiness, stomatitis, weight loss, fever, chill, hyperglycemia

DDI: Serious Vincristine causes neurotoxicity, Imatinib leads to hepatotoxicity

Monitor: CBC, urinalysis, LFTs, coagulation parameters, renal functions, blood glucose,uric acid,allergic reactions & mental status

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