Bisoprolol

Details About Generic Salt ::  Bisoprolol 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Hypertensives

4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM
BISOPROLOL
ß1-ADRENERGIC BLOCKER | ANTI-HYPERTENSIVE
PK: A: Rapid D: Extensive M: Hepatic E: Urine (50%) & feces (<2%)

Indications & Dose: HYPERTENSION PO Adult 2.5-10mg/day, may be increased to 10mg max 20mg/day Elderly Initially 2.5mg/day, may be increased by 2.5-5mg/day max 20mg/day

Contra: Cardiogenic shock, overt cardiac failure, marked sinus bradycardia, heart block greater than first-degree, bronchospasm/asthma, COPD, metabolic acidosis, hypotension, Prinzmetal’s angina, severe peripheral arterial disease, sinus bradycardia

Precautions: first-degree heart block, during drug withdrawal, pheochromocytoma, DM, conduction abnormality, hepatic/renal impairment, Myasthenia gravis, PVD, raynaud’s disease, psoriasis, psychiatric disease, thyrotoxicosis

ADR: Serious: chest pain, HF, bradycardia, orthostatic hypotension, visual disturbances, pulmonary edema, arrhythmias, ischemic colitis, pancreatitis, blood disorder, hepatomegaly, bronchospasm, Others: rash, weight gain, cold extremities, depression, dizziness, headache, malaise, fatigue, insomnia, hypoesthesia, diarrhea, vomiting, nausea, arthralgia, URTI, dyspnea

DDI: Serious Theophylline causes bronchospasm in asthma patients, MAOIs causes HTN, GA causes myocardial depression, Rifampicin increases drug clearance

Diet: With/without food

Monitor: BP, ECG

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