The Brand Name CETAZID Has Generic Salt :: Ceftazidime
CETAZID Is From Company HAMPS BIO Priced :: Rs. N.I.
CETAZID have Ceftazidime is comes under Sub class Cephalosporins of Main Class Anti Infectives
Main Medicine Class:: Anti Infectives Sub Medicine Class :: Cephalosporins
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Indications for Drugs ::
Pneumonia, Cystic fibrosis, Bacterial septicemia, Meningitis, Peritonitis, Skin and Skin-Structure Infections, Endometritis, Pelvic cellulitis, Respiratory tract infections, Urinary tract infections, Febrile neutropenia, Melioidosis, Bone and Joint Infections,G ynecologic Infections, Biliary tract infections, Endophthalmitis
Drug Dose ::
Adults: The adult dosage range for ceftazidime is 1 to 6 gm per day 8 or 12 hourly (IM/IV) in the majority of infections, 1 gm 8 hourly or 2 gm 12 hourly should be given. In urinary tract infections and many less serious infections, 500 mg or 1 gm 12 hourly is usually adequate. In severe infections, especially immunocompromised patients, including those with neutropenia, 2 gm 8 or 12 hourly should be administered. When used as a prophylactic agent in prostatic surgery 1gm should be given at the induction of anesthesia. A second dose should be considered at the time of catheter removal. Neonates (0 – 2 months): 25-60 mg/kg/day IV Q 12h Infants & Children (2 months – 12 years): 30-100 mg/kg/day IV to a maximum of 6 grams per day Q 8-12h. Elderly: Max dose: 3 g daily. Renal impairment: Loading dose: 1 g; maintenance doses based on CrCl. May need to increase doses by 50% in severe infections. Peritoneal dialysis: Loading dose is followed by 500 mg every 24 hr; may add ceftazidime to the dialysis fluid (usually 125-250 mg for 2 litres of dialysis fluid). Haemodialysis: Admin loading dose then 0.5-1 g after each dialysis period. CrCl (ml/min) 31-50 1 g every 12 hr. 16-30 1 g every 24 hr. 6-15 500 mg every 24 hr. <5 500 mg every 48 hr. Contraindication ::
Hypersensitivity to cephalosporins.
Drug Precautions ::
History of penicillin allergy; severe renal impairment; pregnancy, lactation.
Drug Side Effects ::
Hypersensitivity, dizziness, diarrhoea, nausea, vomiting, renal impairment, rash, erythema multiforme, thrombocytopaenia, superinfection, phloebitis and thrombophloebitis at the site of injection. Potentially Fatal: Anaphylactic reactions, nephrotoxicity, pseudomembranous colitis.
Pregnancy category ::
Drug Mode of Action ::
Ceftazidime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Drug Interactions ::
May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level w/ probenecid.