Chloramphenicol

Details About Generic Salt ::  Chloramphenicol 

Main Medicine Class:: Ocular   Sub Medicine Class ::  Anti Infectives

3C. ANTI-INFECTIVES in 3. OCULAR
CHLORAMPHENICOL
DICHLOROACETIC ACID DERIVATIVE | ANTI-INFECTIVE
also comes under 13R. Miscellaneous in 13. Anti-Infectives,  2A. Anti-Infectives in 2. Ear, Nose & Throat (ENT)
PK: A: Readily absorbed D: 0.5-1 L/kg (Vd), extensive M: Hepatic E: Urine

Indications & Dose: BACTERIAL INFECT IN OTITIS EXTERNA TP Adult Applied as ear drops (5 or 10%) | EYE INFECT TP Adult Applied as 0.5% solution or as 1% ointment | MENINGITIS IV Adult 50-100mg/kg/day in divided doses q6h, max 4g/day Child 75-100mg/kg/day divided q6h including infants >30 days | PLAGUE IV Adult 25mg/kg QID 10 days Child > 2 yr: Same as adult dose | TULAREMIA IV Adult 15mg/kg QID 2-3 wk Child Same as adult dose

Contra: Hypersensitivity, treatment of trivial/viral infect, bacterial prophylaxis, pre-existing bone-marrow depression/blood dyscrasias, repeated courses & prolonged treatment

Precautions: Hepatic/renal impairment, G6PD deficiency, neonates

ADR: Serious: Blood disorders, aplastic anemia, bone marrow depression, angioedema, anaphylaxis, gray syndrome in neonates, peripheral neuropathy, optic neuritis, vision loss, colitis, ototoxicity, Others: pruritus, dry mouth, rash, itching, contact dermatitis, fever, nausea, vomiting, diarrhea, abdominal pain, glossitis, confusion, delirium, depression, headache

DDI: Serious Tolbutamide/Chlorpropamide blood glucose-lowering effects reduces by drug, Phenytoin level increases by drug, Tacrolimus/Ciclosporin level markedly increases by drug, Phenobarbital markedly reduces serum drug levels, Vit B12/Iron compounds opposes treatment of anemias, Rifampicin reduces drug level

Monitor: CBC with DC, LFTs, renal function tests, Se drug level

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