Cilostazol

Details About Generic Salt ::  Cilostazol 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Drugs for Vascular disorder

4G. DRUGS FOR VASCULAR DISORDER in 4. CARDIOVASCULAR SYSTEM
CILOSTAZOL
PDE-3 INHIBITOR | VASODILATOR
PK: M: Hepatic E: Urine (74%), feces (20%)

Indications & Dose: INTERMITTENT CLAUDICATION Symptomatic therapy PO Adult 100mg BID

Contra: Hypersensitivity, HF, hemostatic disorders/active bleeding, history of ventricular arrhythmias, QT interval prolongation agents

Precautions: Severe underlying heart disease, moderate-to-severe hepatic impairment, patients with thrombocytopenia, other platelet aggregation inhibitors, strong CYP3A4 inhibitors, moderate/strong CYP3A4 inducers & major CYP3A4 substrates, severe renal impairment

ADR: Serious: Cardiac arrhythmias, chest pain, cardiovascular toxicity, palpitations, edema, Others: Headache, dizziness, diarrhea, nausea, vomiting, skin rashes, rhinitis

DDI: Serious Diltiazem/Clopidogrel/Erythromycin/Ketoconazole increases drug levels, Anagrelide increases inotropic effects, Lovastatin/Cisapride/Simvastatin levels increases by drug, Coumarins may increase risk of bleeding

Diet: 30 min before/2h after food

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