Cisapride

Details About Generic Salt ::  Cisapride 

Main Medicine Class:: Gastrointestinal System   Sub Medicine Class ::  GERD,

7A. GERD, ULCER/ANTACIDS in 7. GASTROINTESTINAL SYSTEM
CISAPRIDE
SUBSTITUTED BENZAMIDE | PROKINETIC DRUG
PK: A: Rapid M: Hepatic E: Urine, feces

Indications & Dose: GASTROOESOPHAGEAL REFLUX DISEASE PO Adult 5-10mg TID-QID, max 40mg/day Child 200µg/kg TID-QID, max 800µg/kg Elderly half the usual doseassociated with decreased gastric motility & in non-ulcer dyspepsia

Contra: CYP450 potent inhibitors, drugs which prolongs QT interval or family history of QT interval prolongation, history of ventricular arrhythmia or torsade de pointes, renal failure, respiratory failure, infants <3 months after birth

Precautions: Renal/hepatic impairment, uncorrected electrolyte disturbances

ADR: Serious: Hypersensitivity reactions, arrhythmia, ventricular tachycardia, ventricular fibrillation, torsade de pointes, QT interval prolongation, extrapyramidal effects, bronchospasm, convulsions, Others: increased urinary frequency, GI disturbances, abdominal cramps, diarrhea, headache & lightheadedness, rash, pruritus

DDI: Serious Clarithromycin/Cimetidine/Diltiazem/Erythromycin/Ketoconazole/Nefazodone increases drug level leads to increase risk of QT prolongation & life-threatening ventricular arrhythmias, Ciclosporin level increased, Alcohol levels are modestly increased

Diet: 15-30min before food & at bedtime

Monitor: ECG, serum electrolytes & renal function before & during treatment

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