The Brand Name CLEXANE Has Generic Salt :: ENOXAPARIN
CLEXANE Is From Company Sanofi Aventis Priced :: Rs. 303.2
CLEXANE have ENOXAPARIN is comes under Sub class Anti Coagulants of Main Class Hematological System
Main Medicine Class:: Hematological System Sub Medicine Class :: Anti Coagulants
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Indications for Drugs ::
Myocardial infarction, Unstable angina, Venous thromboembolism, Deep vein thrombosis
Drug Dose ::
Adult: SC Prophylaxis of venous thromboembolism during surgery Low-moderate risk: 20 mg once daily, start 2 hr before start of procedure. High risk: 40 mg once daily, start 12 hr before start of procedure. Child: <2 mth 750 mcg>2 mth 500 mcg/kg (50 u/kg) 12 hrly. For hip replacement surgery: 40 mg once daily for a further 3 wk. For immobilised patients: 40 mg once daily for at least 6 days or until patient is ambulant, up to a max of 14 days. Deep vein thrombosis 1 mg/kg 12 hrly for 5 days and until oral anticoagulation is established. Prevention of clotting in extracorporeal circulation during haemodialysis 1 mg/kg into the arterial line of the circuit at the start of the dialysis session. Give a further dose of 0.5-1 mg/kg if needed. Unstable angina 1 mg/kg 12 hrly for 2-8 days w/ low dose aspirin. Parenteral Acute ST-elevation myocardial infarction Adult: Initially, 30 mg (3000 u) via IV w/ 1 mg/kg (100 u/kg) via SC given at the same time. Dose should be followed by 1 mg/kg (100 u/kg) via SC 12 hrly for 8 days or until hospital discharge. The 1st 2 SC doses should not exceed 100 mg (10,000 u) each. Patients who undergo PCI: An additional 300 mcg/kg (30 u/kg) via IV given at the time of the procedure if the last SC dose was given >8 hr ago. Elderly: >75 yr SC: 750 mcg/kg (75 u/kg) 12 hrly, w/ max 75 mg (7500 u) for each of the 1st 2 doses.
Hypersensitivity, acute bacterial endocarditis; major bleeding disorder, haemorrhagic stroke, drug-induced thrombocytopenia.
Drug Precautions ::
Renal or hepatic impairment, history of GI ulceration, uncontrolled hypertension, spinal or epidural anaesthesia; lactation and pregnancy; elderly. Periodic blood counts, platelet count and stool occult blood test recommended.
Drug Side Effects ::
Thrombocytopenia, mild bleeding, inj site irritation, pain and ecchymoses, hypersensitivity and erythema. Potentially Fatal: Haemorrhagic complications.
Pregnancy category ::
Drug Mode of Action ::
Enoxaparin is a low molecular weight heparin w/ anticoagulant properties. It acts by enhancing the inhibition rate of activated clotting factors including thrombin and factor Xa through its action on antithrombin III.
Drug Interactions ::
Increased risk of bleeding w/ anticoagulants, platelet aggregation inhibitors (e.g. dipyridamole, salicylates, NSAIDs, sulfinpyrazone). May increase bleeding w/ vit E.