Dacarbazine

Details About Generic Salt ::  Dacarbazine 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
DACARBAZINE
ALKYLATING DRUG, TRIAZENE | ANTI-NEOPLASTIC
PK: D: 0.6 L/kg (Vd) M: Hepatic E: Urine (~40% as unchanged drug)

Indications & Dose: HODGKIN’S DISEASE Combination therapy IV Adult 375mg/m2 on days 1 & 15 with other anti-cancer drugs, regimen may be repeated q4wk Child Same as adult dose | METASTATIC MELANOMA IV Adult 250mg/m2/day for 5 days, repeated q3wk

Contra: Hypersensitivity

Precautions: Hepatic/renal impairment, impaired bone marrow function, children

ADR: Serious: myelosuppression, leukopenia, thrombocytopenia, anaphylactic reactions, hepatic necrosis, renal functions test abnormalities, Others: paresthesia, diarrhea, erythema, facial flushing, pain on inf, alopecia, nausea, vomiting, anorexia

DDI: Serious Levodopa effects reduces by drug

Monitor: CBC with differential, LFTs