Article Contents ::
Details About Generic Salt :: Acarbose
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Insulin , Anti Diabetic drugs
| 8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| ACARBOSE |
| A-GLUCOSIDASE INHIBITOR | ANTI-DIABETIC |
| PK: A: Poor D: 0.32 L/kg (IV) M: GIT E: Urine % Feces |
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Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult Initially 25mg/day, may increase to TID based on tolerance, MD 50-100mg TID, may adjust dose q4-8wk intervals based on 1h PPG levels & tolerance max 50mg TID (<60 kg) or 100mg TID (>60 kg) |
| Contra: Hypersensitivity, DKA, cirrhosis, IBD, colonic ulceration, chronic intestinal diseases, renal impairment, type 1 DM, children & adolescent
Precautions: Increased hypoglycemic effects ADR: Serious: edema, erythema, exanthema, hepatitis, ileus/subileus, jaundice, pneumatosis cystoides intestinalis, thrombocytopenia, urticaria, Others: rash, flatulence, increased transaminases, diarrhea, abdominal pain DDI: Serious Colestyramine increases drug efficacy, Neomycin increases drug efficacy & GI adverse effects Diet: With food (first bite of meal) Monitor: PPG, HbA1c,LFT, SeCr |