Article Contents ::
Details About Generic Salt :: Amlodipine
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Anti Anginals
| 4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM |
| AMLODIPINE |
| CCB | ANTI-HYPERTENSIVE, ANTI-ANGINAL |
| also comes under 4C. Anti-Anginals in 4. Cardiovascular System, |
| PK: A: Well absorbed (PO) D: 21 L/kg (Vd) M: Hepatic E: Urine |
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Indications & Dose: CORONARY ARTERY DISEASE PO Adult 5-10mg ODAngiographically documented | HYPERTENSION PO Adult Initially 5mg OD, increased to 10mg OD, if needed Child 6-17 yr: 2.5-5mg OD Elderly 2.5mg OD | PRINZMETAL’S ANGINA PO Adult 5-10mg/day MD 10mg Elderly 5mg OD | STABLE ANGINA Chronic PO Adult Initially 5mg/day, increased to 10mg, MD 10mg Elderly 5mg OD |
| Contra: Hypersensitivity, cardiogenic shock, unstable angina, acute porphyria
Precautions: Aortic stenosis, hepatic impairment, hypertrophic cardiomyopathy, HF, elderly, children ADR: Serious: hypotension, tachycardia, visual disturbances, abnormal LFTs, SJS, urticaria, peripheral edema, Others: impotence, gingival hyperplasia, myalgia, tremor, depression, dizziness, flushing, headache, GI disturbances, increased micturition, lethargy DDI: Serious Nitrates (long acting) enhances hypotensive effect of drug, Nitroglycerin (sublingual) enhances hypotensive effect of drug, Diltiazem increases drug level, Ritonavir/Indinavir modest to markedly increases in drug level Diet: With/without food Monitor: HR,BP, Edema |
