The Brand Name APIDRA Has Generic Salt :: INSULIN 

APIDRA  Is From Company Aventis Priced :: Rs. 550

APIDRA have INSULIN is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Diabetes mellitus

Drug Dose ::

Adult: SC DM Dosage should be individualised and adjusted based on patient’s glycaemic response. Usual range: 0.5-1 u/kg/day. Morning: Give 2/3rds of daily insulin SC Ratio of regular insulin to NPH (isophane) insulin 1:2 Evening: Give 1/3 of daily insulin SC

Contraindication ::

Hypoglycaemia.Hypersensitivity to any of the components.

Drug Precautions ::

Pregnancy (insulin requirements tend to fall during the 1st trimester, increase during the 2nd and 3rd) and lactation. Regular monitoring of HbA1c and blood glucose concentrations.

Drug Side Effects ::

Adverse events commonly associated with human insulin therapy include the following: Allergic reactions. Injection site reaction, lipodystrophy, pruritus, rash, lipoatrophy, hypokalaemia, blurred vision. Hypoglycaemia, insulin resistance

Pregnancy category ::

2

Drug Mode of Action ::  

Insulin lowers blood glucose levels. It regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal. The various insulin formulations are classified according to their durations of action after SC Inj. They are divided into short-, intermediate-, or long-acting insulin. Soluble insulin (also known as ‘neutral insulin’ or ‘regular insulin’) is a short-acting preparation. To extend the duration of action of insulin, preparations are formulated as suspensions in 2 methods. The 1st method involves complexing insulin with a protein so that it is slowly released, e.g. protamine zinc insulin (contains an excess of protamine) and isophane insulin (or NPH insulin which contains equal amounts of protamine and insulin). An alternative method is particle size modification e.g. insulin zinc suspensions. While all the formulations can be admin by SC inj, most by IM inj, only soluble insulin can be admin by IV. Compared to SC inj, IM admin usually has a faster onset of action, with a shorter duration of action.

Drug Interactions ::

Oral hypoglycemic agents, MAOIs, nonselective ?-blocker, ACE inhibitors, salicylates, alcohol, anabolic steroids & sulphonamides may reduce insulin requirement. OCs, thiazides, glucocorticoids, thyroid hormones, ?-sympathomimetics & danazol may increase insulin requirements. Octreotide/lanreotide may both decrease & increase insulin requirement. ?-blockers may mask symptoms of hypoglycemia. Alcohol may intensify or reduce hypoglycemic effect of insulin.