Article Contents ::
Details About Generic Salt :: Benazepril
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Drugs for Cardiac Failure , Shock
| 4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM |
| BENAZEPRIL |
| ACEI | ANTI-HYPERTENSIVE |
| also comes under 4A. Drugs for Cardiac Failure & Shock in 4. Cardiovascular System |
| PK: A: Rapid D: 8.7 L/kg (Vd) M: Hepatic E: Urine |
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Indications & Dose: HEART FAILURE PO Adult Initially 2.5mg OD, max 20mg/day | HYPERTENSION PO Adult Initially 10mg/day (if not receiving diuretic), then 20-80mg/day 1 or 2 divided doses. Patients on diuretics should discontinue the drug prior to initiation of benazepril, if not possible then start with low initial dose of benazepril 5mg/day Child >6 yr: Initially 0.2mg/kg/day (up to 10mg/day) as monotherapy, dosing range: 0.1-0.6 mg/kg/day, max 40mg/day Elderly Initially 5-10mg/day in single or divided doses, usual range 20-40mg/day |
| Contra: Hypersensitivity, history of angioedema
Precautions: Severe aortic stenosis, collagen vascular disease, CVD, DM, hypertrophic cardiomyopathy, renal artery stenosis, renal impairment, before/during/immediately after major surgery ADR: Serious: Blood disorders, renal/renovascular dysfunction, nephrotic syndrome, hyperkalemia, hyponatremia, HF, hypovolemia, MI, stroke, tachycardia, chest pain, SJS, TEN, angioedema, Others: hyperglycemia, postural dizziness, headache, serum creatinine increased, cough DDI: Serious Rofecoxib increases BP, Furosemide leads to first-dose hypotension Monitor: BP, Secr & potassium, CBC |
