Article Contents ::
Details About Generic Salt :: Glipizide
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Insulin , Anti Diabetic drugs
| 8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| GLIPIZIDE |
| SULFONYLUREA | ANTI-DIABETIC |
| PK: A: Rapid D: 10-11 L M: Hepatic E: Urine 60% to 80%) & feces (11%) |
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Indications & Dose: TYPE 2 DIABETES MELLITUS Chronic PO Adult Initially 2.5–5mg/day, up to 15mg may be given as single dose, max 20mg/day |
| Contra: Hypersensitivity, type 1 DM, DKA
Precautions: Elderly, hepatic/renal impairment ADR: Serious: Hypoglycemia, hyponatremia, thrombocytopenia, hepatitis, maculopapular eruptions, morbilliform eruptions, eczema, Others: dizziness, headache, epigastric fullness, nausea, paresthesia, myalgia, constipation, nervousness, myalgia, insomnia DDI: Serious Fluconazole causes hypoglycemic coma, Cyclosporine levels are increased by two folds, Cholestyramine reduces drug absorption, Rifampicin reduces drug effects, Erythromycin/Clarithromycin/Gatifloxacin/Heparin results in hypoglycemia Diet: Before food (30 mins) Monitor: Hypoglycemia, blood glucose & HbA1c |