The Brand Name GMYCIN Has Generic Salt :: Gentamicin 

GMYCIN  Is From Company Bpl Ph. Priced :: Rs. 8.84

GMYCIN have Gentamicin is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Pneumonia, Cystic fibrosis, Meningitis, Peritonitis, Endocarditis, Susceptible infections, Septicaemia, Pelvic inflammatory disease, Endometritis, Biliary tract infections, Granuloma inguinale, Listeriosis, Gastroenteritis, Plague, Cat scratch disease, Brucellosis, Otitis externa, Surgical infections, Skin infections.

Drug Dose ::

Adult: IM Susceptible infections 3-5 mg/kg/day in divided doses 8 hrly for 7-10 days. Surgical prophylaxis 120 mg before induction of anesth, w/ penicillin, vancomycin or teicoplanin. Pediatric Up to 2 weeks: 3 mg/kg/every 12 hours 2 weeks to 12 years: 2 mg/kg/every 8 hours or as directed by the physician. Renal impairment: Haemodialysis: Administer dose after dialysis session and monitor levels. CrCl (ml/min) >60 Administer every 8 hr. 40-60 Administer every 12 hr. 20-40 Administer every 24 hr. <20 Loading dose, monitor levels. Contraindication ::

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.

Drug Precautions ::

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.

Drug Side Effects ::

Dizziness or vertigo; acute renal failure, interstitial nephritis, acute tubular necrosis; electrolyte imbalances; transient elevation of serum bilirubin and aminotransferases; purpura; nausea, vomiting; convulsions, mental depression, hallucinations. Atrophy or rat necrosis at inj sites. Potentially Fatal: Nephrotoxicity, ototoxicity and neuromuscular blockade (may unmask or aggravate myasthaenia gravis).

Pregnancy category ::

4

Drug Mode of Action ::  

Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Drug Interactions ::

Synergistic with ampicillin, benzylpenicillin and other beta-lactam antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids. May reduce renal clearance of zalcitabine and induce hypocalcaemia when used with biphosphonates. Not to be used with agalsidase alfa or beta as it may inhibit ?-galactosidase activity. Potentially Fatal: Increased incidence of ototoxicity when combined with ethacrynic acid and furosemide. Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone and indometacin potentiate nephrotoxicity. Potentiates neuromuscular blocking agents.