The Brand Name GTROL Has Generic Salt :: Glipizide 

GTROL  Is From Company Mano Priced :: Rs. 16.5

GTROL have Glipizide is comes under Sub class Insulin , Anti Diabetic drugs of  Main Class Endocrine,Steroid Hormones , Metabolic System

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System  Sub Medicine Class :: Insulin , Anti Diabetic drugs 

Indications for Drugs ::

Type 2 DM

Drug Dose ::

Adult: PO Initial: 2.5-5 mg/day as a single dose, may increase slowly. Doses >15 mg may be given in 2 divided doses. Max: 40 mg/day. Hepatic impairment: Severe: Contraindicated.

Contraindication ::

Hypersensitivity. Type 1 DM; ketoacidosis; severe renal or hepatic insufficiency. Pregnancy, lactation.

Drug Precautions ::

Hypoglycaemia, stress, elderly. Thyroid impairment; moderate hepatic or renal impairment. Monitor blood glucose concentration.

Drug Side Effects ::

GI upsets, diarrhoea, nausea; allergic skin reactions, leucopenia, thrombocytopenia, agranulocytosis, hyponatraemia; jaundice; haemolytic anaemia, pancytopenia. Potentially Fatal: Hypoglycaemia in presence of renal or hepatic damage and alcohol.

Pregnancy category ::

3

Drug Mode of Action ::  

Glipizide stimulates insulin release from pancreatic ?-cells and reduces glucose output from the liver. It also increases insulin sensitivity at peripheral target sites.

Drug Interactions ::

Increased plasma concentration w/ certain antifungals (e.g. miconazole, fluconazole). Protein-bound drugs (e.g. NSAIDs, other sulfonamides, oral anticoagulants, hydantoins), probenecid, MAOIs, and chloramphenicol may potentiate hypoglycaemic action of glipizide. Diminished therapeutic effect w/ thiazides, other diuretics, phenothiazines, thyroid agents, oestrogens, OC, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers, rifampicin and isoniazid. Concomitant use w/ ?-blockers may impair glucose tolerance, increase frequency or severity of hypoglycaemia and block hypoglycaemia-induced tachycardia. Decreased serum concentration w/ colesevelam.