Article Contents ::
Details About Generic Salt :: Nicorandil
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Anti Anginals
| 4C. ANTI-ANGINALS in 4. CARDIOVASCULAR SYSTEM |
| NICORANDIL |
| POTASSIUM CHANNEL OPENER | ANTI-ANGINAL |
| PK: A: Well absorbed M: Hepatic E: Urine |
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Indications & Dose: ANGINA PO Adult Initially 10mg BID max 30mg BID | HEART FAILURE Acute IV Adult Inj: 200µg/kg (400-2500µg/mL) over 5 min, followed by continuous inf of 200µg/kg/h max 50-200µg/kg/h | UNSTABLE ANGINA IV Adult Inf: 2mg/h (100-300µg/mL), adjust according to response max 6mg/h |
| Contra: Cardiogenic shock, left ventricular failure
Precautions: Low systolic BP, edema, MI, hypovolemia ADR: Serious: Cutaneous vasodilatation, myalgia, angioedema, hepatic dysfunction, tachycardia, Others: dizziness, flushing, nausea, vomiting, weakness, skin rashes, ulceration DDI: Serious Corticosteroids causes GI perforations, Tadalafil/Sildenafil/Vardenafil causes serious hypotension/MI, TCAs/Alcohol potentiates hypotensive effects |
