Article Contents ::
Details About Generic Salt :: Rosiglitazone
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Insulin , Anti Diabetic drugs
| 8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| ROSIGLITAZONE |
| THIAZOLIDINEDIONE | ANTI-DIABETIC |
| PK: A: Rapid D: 17.6 L (Vdss) M: Hepatic E: Urine (64%) & feces (23%) |
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Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult Combination with sulfonylurea/metformin: Initially 4mg/day single dose or divided doses, increase to 8mg/day if response is inadequate after 8-12 wk. Reduce sulfonylurea dose if hypoglycemia occurs | Mono therapy PO Adult Initially 4mg/day single dose or divided doses, increase to 8mg/day if response is inadequate after 8-12 wk |
| Contra: Hypersensitivity, HF, hepatic impairment
Precautions: CVD, combination with insulin, substitute insulin during peri-operative period ADR: Serious: HF, cardiac ischemia, hypoglycemia, hepatic toxicity, altered blood lipids, hematuria, Others: fatigue, insomnia, vertigo, proteinuria, GI disturbances, weight gain, edema, headache, dizziness, arthralgia, hypoesthesia DDI: Serious Insulin Regular causes peripheral edema, Ketoconazole increases drug level, NSAIDs leads to fluid retention, Gatifloxacin/Fibrates results in hypoglycemia Diet: With/without food Monitor: Glucose, HbA1c, signs/symptoms of HF & LFTs |