Indomethacin

Details About Generic Salt ::  Indomethacin 

Main Medicine Class:: Musculoskeletal Disorders , Pain   Sub Medicine Class ::  Analgesics , Anti inflammatory Drugs

12E. ANALGESICS & ANTI-INFLAMMATORY DRUGS in 12. MUSCULOSKELETAL DISORDERS & PAIN
INDOMETHACIN
NSAID | ANALGESIC & ANTI-INFLAMMATORY
PK: A: Prompt & extensive (PO, IR) D: 0.34-1.57 L/kg (Vd) M: Hepatic E: Urine (60%), feces (33%)

Indications & Dose: ANKYLOSING SPONDYLITIS PO Adult 25mg BID/TID dose may be increase by 25-50mg/day at weekly intervals max 150-200mg/day | Symptomatic therapy PO Adult ER: 75mg/day in morning or at HS dose may be increase to 75mg BID 1 month | BURSITIS & TENDINITIS OF SHOULDER Acute PO Adult 75-150mg/day in 3-4 divided doses 7-14 days | GOUTY ARTHRITIS Acute PO Adult 50mg TID until all signs & symptoms subside | OSTEOARTHRITIS PO Adult 25mg BID/TID dose may be increase by 25-50mg/day at weekly intervals max 150-200mg/day | Symptomatic therapy PO Adult ER: 75mg/day in morning or at HS, dose may be increase to 75mg BID 1 month | RHEUMATOID ARTHRITIS PO Adult 25mg BID/TID dose may be increased by 25-50mg/day at weekly intervals max 150-200mg/day | Symptomatic therapy PO Adult ER: 75mg/day in morning or at HS, dose may be increase to 75mg BID 1 month | SYMPTOMATIC DUCTUS ARTERIOSUS IV Child Neonate: Inf: Initially 100–200µg/kg single dose over 20-30min, followed by 2 doses of 100µg/kg at 24h intervals, if residual patency present, give 100µg/kg further 3doses at 24h intervals

Contra: Hypersensitivity, CABG surgery, patients with a history of proctitis/recent rectal bleeding, active bleeding, thrombocytopenia, coagulation defects, untreated infect, congenital heart disease, necrotizing enterocolitis

Precautions: History of GI disease, asthma, depression, epilepsy, parkinsonism, HTN, hepatic/renal impairment, elderly

ADR: Serious: Severe GI bleeding, blood disorders, nephrotoxicity, hematuria, nephropathy, HF, hepatotoxicity, angioedema, TEN, renal disorders, pulmonary HTN, intracranial bleeding, fluid retention, SJS, Others: GI disturbances, nausea, diarrhea, headache, vertigo, dizziness, nervousness, depression, drowsiness, visual disturbances, photosensitivity, fever, rashes

DDI: Serious Aspirin antiplatelet effects is antagonised, β-blockers/Diuretics efficacy reduced, Haloperidol leads to profound drowsiness & confusion, Penicillamine/Misoprostol/Prednisolone levels raised, Diflunisal raises drug levels, Probenecid reduces drug clearance, Vancomycin renal clearance reduced in premature neonates, Lithium/Digoxin toxicity raises

Diet: With food

Monitor: Weight gain, edema, renal function test, observe for bleeding, bruising, evaluate GI effects, mental confusion, disorientation, CBC, LFTs, ophthalmologic exams with prolonged therapy

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