Labetalol

Details About Generic Salt ::  Labetalol 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Miscellaneous

4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM
LABETALOL
NON-CARDIOSELECTIVE ß-ADRENERGIC BLOCKER | ANTI-HYPERTENSIVE
also comes under 16C. Miscellaneous in 16. Anesthetics
PK: A: Well absorbed D: 3-16 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: HYPERTENSION PO Adult 100mg BID, if needed gradually increased to 200-400mg BID based on response Child 1 month-12 yr: 1-2mg/kg TID/QID, 12-18 yr: Initially 50-100mg BID increased if required at intervals of 3-14 days to usual dose of 200-400mg BID, max 2.4g/day Elderly Initially 50-100mg BID MD 100-200mg | IV Adult Inf: 2mg/min Child 1 month-12 yr: 250-500µg/kg as single dose max 20mg, 12-18 yr: 50mg over 1 min, repeated after 5 min if necessary max total dose 200mg | HYPERTENSION AFTER MYOCARDIAL INFARCTION IV Adult Inf: 15mg/h, gradually increased until satisfactory response is obtained or when dose of 120mg/h is reached | HYPERTENSION IN PREGNANCY IV Adult Inf: 20mg/h, then doubled q30min until a satisfactory response is obtained/dose of 160mg/h is reached | HYPERTENSIVE EMERGENCIES IV Adult 20mg IV push over 2 min, may administer 40-80mg at 10 min intervals, up to 300mg total dose, Inf: Initially 2mg/min, increase as required, max 300mg total dose Child Inf: Neonate: 500µg/kg/h adjusted at intervals of at least 15 min according to response, max 4mg/kg/h, 1 month-12 yr: Initially 0.5-1mg/kg/h adjusted at intervals of 15 min according to response, max 3mg/kg/h, 12-18 yr: 30-120mg/h adjusted at intervals of 15 min according to response | HYPOTENSIVE ANESTHESIA IV Adult Initially 10-20mg, if no response after 5 min increase by 5-10mg

Contra: hypersensitivity, sinus bradycardia, sinus node dysfunction, heart block greater than first degree, cardiogenic shock, uncompensated HF, Prinzmetal’s angina, hypotension, metabolic acidosis, COPD, bronchospasm/asthma, conditions associated with severe & prolonged hypotension

Precautions: HF, DM, myasthenia gravis, PVD, psoriasis, pheochromocytoma, psychiatric disease, first-degree heart block, renal/hepatic impairment, during drug withdrawal, pulmonary disease, hyperthyroidism, thyrotoxicosis, elderly, discontinue 1 day before induction of anesthesia

ADR: Serious: Arrhythmias, agranulocytosis, thrombocytopenia, pulmonary edema, hypoglycemia, HF, bronchospasm, peripheral vasoconstriction, bradycardia, blurred vision, Others: dry eyes, nasal congestion, nausea, diarrhea, constipation, erectile dysfunction, decreased libido, muscle cramps, joint pain, wheezing, rash, Fatigue, asthenia, anxiety, depression, paresthesia, drowsiness, insomnia, memory loss, nightmares

DDI: Serious Metoclopramide causes fatal cardiac arrest with IV administration of both the drugs, Adrenaline hypertensive effect increases by drug, Imipramine levels increases

Diet: With food

Monitor: BP (standing & sitting/supine), pulse, cardiac monitor

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