Modafinil

Details About Generic Salt ::  Modafinil 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Nootropics , Neurotonics,Stimulants

1G. NOOTROPICS & NEUROTONICS/STIMULANTS in 1. NERVOUS SYSTEM
MODAFINIL
NONAMPHETAMINE CNS STIMULANT | ANALEPTIC
PK: D: 0.9 L/kg (Vd) M: Hepatic E: Urine (as metabolites, <10% as unchanged drug)

Indications & Dose: NARCOLEPSY PO Adult 200mg/day single dose in morning | OBSTRUCTIVE SLEEP APNEA/HYPOPNEA SYNDROME PO Adult 200mg/day single dose in morning | SHIFT WORK SLEEP DISORDER PO Adult 200mg single dose taken ~1h prior to start of work shift

Contra: Hypersensitivity, uncontrolled/moderate-to-severe HTN, cardiac arrhythmias, history of left ventricular hypertrophy, ischemic ECG changes, chest pain/other signs of mitral valve prolapse, history of psychosis/depression/mania

Precautions: CVD, hepatic/renal impairment, psychiatric disorders, sleep disorders, Tourette’s syndrome, recent MI, unstable angina, severe hepatic impairment, hyperthyroidism, glaucoma, anxiety, drug abuse, children

ADR: Serious: tremor, tachycardia, SJS, erythema multiforme, TEN, Benign pruritic rashes, angioedema, suicidal ideation, mania, alkaline phosphatase, HTN, Others: palpitations, dyskinesia, Headache, nervousness, insomnia, agitation, confusion, psychosis, depression, anxiety, GI disturbances, nausea, abdominal pain, dry mouth, diarrhea, dyspepsia, constipation, dizziness, anorexia

DDI: Serious Diazepam level increases by drug, Ciclosporin/Alprazolam/Midazolam/Triazolam level reduces by drug, Ethinylestradiol level reduces slightly by drug, Clomipramine levels increases by drug, MAOIs may develop acute dyskinesia & symptoms serotonin syndrome

Monitor: Levels of sleepiness, BP, BMI & weight loss, severe skin reactions, development/exacerbation of psychiatric symptoms

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