The Brand Name OMEPREN Has Generic Salt :: Omeprazole
OMEPREN Is From Company Blue Cross Priced :: Rs. N.I./33.00
OMEPREN have Omeprazole is comes under Sub class GERD, of Main Class Gastrointestinal System
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: GERD,
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Indications for Drugs ::
Peptic ulcer, H. pylori infection, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Oesophagitis, Acid-related dyspepsia, NSAID-associated ulceration
Drug Dose ::
Adult: PO Peptic ulcer 20 mg once daily. Severe: 40 mg/day. Duration: Duodenal ulcers: 4 wk; Gastric ulcers: 8 wk. Maintenance: 10-20 mg once daily. NSAID-associated ulceration 20 mg/day. Eradication of H. pylori infection Dose varies w/ regimen: 20 mg once daily or 40 mg/day in 1-2 divided doses. To use w/ antibiotics. GERD 20 mg once daily for 4 wk, may continue for another 8 wk if needed. Maintenance: 10 mg/day. Zollinger-Ellison syndrome Initial: 60 mg once daily. Maintenance: 20-120 mg/day. Give doses >80 mg in 2 divided doses. Prophylaxis of acid aspiration during general anesth Initial: 40 mg the evening before surgery and another 40 mg 2-6 hr pre-op. Acid-related dyspepsia 10 or 20 mg/day 2-4 wkly. Erosive oesophagitis 20 mg/day for 4-8 wk. Maintenance: 20 mg/day for up to 12 mth of total therapy inclusive of treatment period. IV Gastric and duodenal ulcers; Reflux oesophagitis 40 mg once daily. Prophylaxis of acid aspiration during general anesth 40 mg, to be completed 1 hr before the surgery.
Known hypersensitivity to any of its component.
Drug Precautions ::
Exclude malignancy, prolonged use, hepatic impairment. Pregnancy, lactation, children <1 yr. elderly and asians (increased bioavailability). Drug Side Effects ::
Diarrhoea, nausea, fatigue, constipation, vomiting, flatulence, acid regurgitation, taste perversion, arthralgia, myalgia, urticaria, dry mouth, dizziness, headache, paraesthesia, abdominal pain, skin rashes, weakness, back pain, upper respiratory infection, cough. Potentially Fatal: Anaphylaxis.
Pregnancy category ::
Drug Mode of Action ::
Omeprazole is a substituted benzimidazole gastric antisecretory agent and is also known as PPI. It blocks the final step in gastric acid secretion by specific inhibition of H+/K+ ATPase enzyme system present on the secretory surface of the gastric parietal cell. Both basal and stimulated acid are inhibited.
Drug Interactions ::
Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin. Increased risk of digoxin-induced cardiotoxic effects. May increase plasma concentration benzodiazepines (e.g. diazepam), clarithromycin and methotrexate. Decreased absorption of itraconazole, ketoconazole, posaconazole, dasatinib, iron salts. May prolong elimination of diazepam, cilostazol, phenytoin and ciclosporin. May reduce the antiplatelet effect of clopidogrel. Potentially Fatal: May decrease plasma concentrations and pharmacological effects of rilpivirine, nelfinavir and atazanavir.