Details About Overdose or Poisoning Generic Salt :: Bromocriptine Bromocriptine Drug Pharmacology :: I. Pharmacology. Bromocriptinemesylate is a semisynthetic derivative of the ergopeptide group ofergot alkaloids with dopaminergic agonist effects. It also has minoralpha-adrenergic antagonist properties. The dopaminergic effectsaccount for its inhibition of prolactin secretion and its beneficialeffects in the treatment of...
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Details About Overdose or Poisoning Generic Salt :: Antivenom, Latrodectus Mactans, Black Widow Spider Antivenom, Latrodectus Mactans (Black Widow Spider) Drug Pharmacology :: I. Pharmacology. To produce the antivenom, horses are hyperimmunized with Latrodectus mactans(black widow spider) venom. The lyophilized protein product from pooledequine sera contains antibodies specific to certain venom fractions...
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Details About Overdose or Poisoning Generic Salt :: Unithiol, DMPS Unithiol (DMPS) Drug Pharmacology :: I. Pharmacology.Unithiol (DMPS; 2,3-dimercaptopropanol-sulfonic acid), a dimercaptochelating agent that is a water-soluble analog of BAL (see BAL[Dimercaprol]), is used in the treatment of poisoning by several heavymetals, principally mercury, arsenic, and lead. Available on theofficial formularies of...
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Details About Overdose or Poisoning Generic Salt :: Physostigmine And Neostigmine Physostigmine and Neostigmine Drug Pharmacology :: I. Pharmacology. Physostigmineand neostigmine are carbamates and reversible inhibitors ofacetylcholinesterase, the enzyme that degrades acetylcholine. Theyincrease concentrations of acetylcholine, causing stimulation of bothmuscarinic and nicotinic receptors. The tertiary amine structure ofphysostigmine allows it to penetrate...
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Details About Overdose or Poisoning Generic Salt :: Octreotide Octreotide Drug Pharmacology :: I. Pharmacology./b> Octreotideis a synthetic polypeptide and a long-acting analog of somatostatin. Itsignificantly antagonizes pancreatic insulin release and is useful forthe management of poisonings from drug-induced endogenous secretion ofinsulin-, oral sulfonylurea–, and quinine-induced hyperinsulinemic andhypoglycemic poisonings. Octreotide also...
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Details About Overdose or Poisoning Generic Salt :: DTPA DTPA Drug Pharmacology :: I. Pharmacology. Diethylenetriaminepentaacetate(Zn-DTPA and Ca-DTPA) is a chelating agent that is used in a calcium orzinc salt form and functions by forming a chelate with metal ions(plutonium, americium, curium) that then can be excreted in urine. DTPAhas a plasma...
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Details About Overdose or Poisoning Generic Salt :: Neuromuscular Blockers Neuromuscular Blockers Drug Pharmacology :: I. Pharmacology./b> Neuromuscularblocking agents produce skeletal muscle paralysis by inhibiting theaction of acetylcholine at the neuromuscular junction. Depolarizing agents(eg, succinylcholine; Table III–11) depolarize the motor end plate andblock recovery; transient muscle fasciculations occur with the initialdepolarization....
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Details About Overdose or Poisoning Generic Salt :: Bretylium Bretylium Drug Pharmacology :: I. Pharmacology. Bretyliumis a quaternary ammonium compound that is an effective type IIIantifibrillatory drug and also suppresses ventricular ectopic activity.It increases the threshold for ventricular fibrillation and reduces thedisparity in action potential duration between normal and ischemictissue, which is...
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Details About Overdose or Poisoning Generic Salt :: Methocarbamol Methocarbamol Drug Pharmacology :: I. Pharmacology. Methocarbamolis a centrally acting muscle relaxant. It does not directly relaxskeletal muscle and does not depress neuromuscular transmission ormuscle excitability; muscle relaxation is probably related to itssedative effects. After intravenous administration, the onset of actionis nearly immediate....
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Details About Overdose or Poisoning Generic Salt :: Morphine Morphine Drug Pharmacology :: I. Pharmacology. Morphineis the principal alkaloid of opium and is a potent analgesic andsedative agent. In addition, it decreases venous tone and systemicvascular resistance, resulting in reduced preload and afterload.Morphine is absorbed variably from the GI tract and usually...
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