Pyrazinamide

Details About Generic Salt ::  Pyrazinamide 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Drugs for Tuberculosis

13O. DRUGS FOR TUBERCULOSIS in 13. ANTI-INFECTIVES
PYRAZINAMIDE
NIACINAMIDE DERIVATIVE | ANTI-TB
PK: A: Well absorbed D: Widely into body fluids & tissues M: Hepatic E: Urine

Indications & Dose: TUBERCULOSIS PO Adult Daily therapy: 40-55 kg: 1g, 56-75 kg: 1.5g, 76-90 kg: 2g, DOT therapy: 40-55 kg: 2g twice weekly or 1.5g thrice weekly, 56-75 kg: 3g twice weekly or 2.5g thrice weekly, 76-90 kg: 4g twice weekly or 3g thrice weekly Child Daily therapy: 15-30mg/kg/day, max 2g/day, DOT therapy: 50mg/kg/dose, max 2g/dose | TUBERCULOSIS IN HIV EXPOSED/INFECTED PO Child 20-40mg/kg/dose OD, max 2g/day

Contra: Hypersensitivity, acute gout, hepatic damage

Precautions: Porphyria, DM, alcoholics, hepatic/renal impairment, children

ADR: Serious: hepatotoxicity, splenomegaly, hepatomegaly, jaundice, convulsions, acute HTN, thrombocytopenia, sideroblastic anemia, arthralgia, myalgia, angioedema, Others: pellagra, anorexia, nausea, vomiting, PUD, photosensitivity, fever, malaise, skin rashes, dysuria

DDI: Serious Ciclosporin causes toxic myopathy, Probenecid/Benzbromarone efficacy reduces, Methotrexate/Alcohol increases risk of hepatotoxicity, Allopurinol induces hyperuricemia

Diet:

Monitor: LFT, serum uric acid, sputum culture, chest x-ray

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