Sotalol

Details About Generic Salt ::  Sotalol 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

4B. ANTI-ARRHYTHMICS in 4. CARDIOVASCULAR SYSTEM
SOTALOL
NON-SELECTIVE ß-BLOCKER | ANTI-ARRHYTHMIC
PK: A: Complete D: 1.2-2.4L/kg (Vd) M: None E: Urine

Indications & Dose: VENTRICULAR ARRHYTHMIAS PO Adult 80mg BID then increase to 240-320mg/day Child Neonates: Initially 1mg/kg BID, increased as necessary q3-4days max 4mg/kg BID, 1 month-12 yr: Initially 1mg/kg BID, increased as necessary q2-3 days max 4mg/kg BID (max 80mg BID as total dose) | IV Adult 75-150mg over 5 hr BID

Contra: Hypersensitivity, asthma, sinus bradycardia, cardiogenic shock, HF, COPD, congenital/acquired long-QT syndrome, hypokalemia

Precautions: hepatic/renal impairment, DM, anaphylactic reactions, PVD, myasthenia gravis, MI, bronchospastic disease, psychiatric disease, elderly

ADR: Serious: torsade de pointes, bradycardia, proarrhythmia, syncope, CHF, extremity pain, visual problems, asthma, impotence, QT interval prolongation, Others: sleep problems, fatigue, dizziness, anxiety, weakness, flatulence, nausea

DDI: Serious Flecainide bradycardia & fatal AV block, Disopyramide causes asystole, Amiodarone causes hypotension, ventricular fibrillation & asystole, Terfenadine causes torsade de pointes arrhythmia, Quinidine increases risk of torsade de pointes arrhythmia, Diltiazem leads to severe bradyarrhythmias, Diuretics precipitate the life-threatening torsade de pointes arrhythmias, Gatifloxacin/Chlorpromazine/Moxifloxacin/Paliperidone/Sparfloxacin prolongs QT interval

Diet: With/without food

Monitor: Secr, vital signs, ECG, Electrolyte levels, signs & symptoms of drug induced lupus syndrome,HF

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