Tapentadol

Details About Generic Salt ::  Tapentadol 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Opioid Analgesics

1I. OPIOID ANALGESICS in 1. NERVOUS SYSTEM
TAPENTADOL
OPIOID ANALGESIC
PK: A: Rapid & complete D: Vd:442-638L (IV) M: Liver E: Urine

Indications & Dose: PAIN Acute/Moderate-to-severe PO Adult Day 1: 50-100mg q4-6h as needed max 700mg/day, may administer second dose after >1h; Day 2 & subsequent dose: 50-100mg q4-6h as needed max 600mg/day

Contra: Impaired pulmonary function (severe respiratory depression, acute/severe asthma, hypercapnia), paralytic ileus, use of MAO inhibitors within 14 days, severe hepatic/renal impairment

Precautions: Respiratory disease, CNS depression or coma, biliary tract dysfunction/acute pancreatitis, patients with head injury, moderate hepatic impairment, mild-to-moderate renal impairment, history of seizure/condition predisposing patients to seizure, elderly, debilitated patients

ADR: Serious: Respiratory depression, Others: dizziness, nausea, vomiting, fatigue, pruritus, constipation, UTI, arthralgia, hot flushes

DDI: Serious Desmopressin/CNS Depressants/MAOIs/SSRIs/Thiazides effects increases, Droperidol/Amphetamine/Phenothiazines/Sibutramine increases drug effect

Diet: With/without food

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