Details About Generic Salt ::  Albumin

Main Medicine Class:: Plasma protein fraction   

(al-BYOO-MIN human)
Albuminar-5, Albuminar-25, Albunex, Albutein 5%, Albutein 25%, Buminate 5%, Buminate 25%, Plasbumin-5, Plasbumin-25
Class: Plasma protein fraction

 

Drugs Class ::

 Action Maintains plasma colloid osmotic pressure and serves as carrier of intermediate metabolites in transport and exchange of tissue products.

Indications for Drugs ::

 Indications Symptomatic relief and supportive treatment in management of shock, burns, hypoprothrombinemia, adult respiratory distress syndrome, cardiopulmonary bypass, acute liver failure, acute nephrosis, sequestration of protein-rich fluids, erythrocyte resuspension, hypotension or shock during renal dialysis, hyperbilirubinemia and erythroblastosis fetalis.

Drug Dose ::

 Route/Dosage

Burns

Initial treatment usually consists of large amounts of crystalloid infusions (eg, normal saline, Lactated Ringer’s) with lesser amounts of 5% albumin to maintain adequate plasma volume. After first 24 hr, ratio of albumin and crystalloid should maintain plasma albumin level of » 2.5 g ± 0.5 g/100 ml or total plasma protein level of about 5.2 g/100 ml. This is best achieved with albumin 25% solution.

NORMAL SERUM ALBUMIN, 5%

Shock

Give as rapidly as necessary to improve patient’s condition and restore normal blood volume. ADULTS: Initial dose: IV 500 ml of 5% albumin given as rapidly as tolerated. If response in 30 min is inadequate, give additional 500 ml. In patients with slightly low or normal blood volume, rate is 2 to 4 ml/min. CHILDREN: IV Rate of administration is ¼ to ½ adult rate. NEONATES & INFANTS: IV 10 to 20 ml/kg 5% albumin based on clinical response, BP and assessment of anemia.

Hypoproteinemia

To replace protein loss, 5% albumin may be given.

ALBUMIN HUMAN, 25%

Shock

ADULTS & CHILDREN: Initial dose: IV Determined by patient’s condition and response to treatment. Therapy is guided by degree of venous or pulmonary congestion or Hct measurements.

Hypoproteinemia

ADULTS: IV 50 to 75 g/day at rate not exceeding 2 ml/min. CHILDREN: IV 25 g/day at rate not exceeding 2 ml/min.

Acute Nephrosis

ADULTS: IV 100 ml 25% albumin in combination with loop diuretic repeated daily for 7 to 10 days.

Renal Dialysis

ADULTS: IV Approximately 100 ml 25% albumin.

Hyperbilirubinemia and Erythroblastosis Fetalis

NEONATES & INFANTS: IV 1 g/kg 1 to 2 hr before transfusion.

Contraindication ::

 Contraindications Severe anemia; cardiac failure; renal insufficiency; presence of normal or increased intravascular volume; chronic nephrosis; hypoprothrombinemic states associated with chronic cirrhosis; malabsorption; protein-losing enteropathies, pancreatic insufficiency; undernutrition.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Special risk patients: Circulatory overload may develop in patients with CHF, renal insufficiency or stabilized chronic anemia. Concomitant blood administration: Relative anemia can be avoided by supplementing or replacing large quantities of albumin with whole blood. Hepatic or renal impairment: Caution is needed because of added protein load.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Hypotension after rapid infusion (> 10 ml/min) or intra-arterial administration to patients undergoing cardiopulmonary bypass; rapid administration may cause vascular overload, dyspnea or pulmonary edema. OTHER: Allergic or pyogenic reactions (characterized by fever and chills).

Drug Mode of Action ::  

 Action Maintains plasma colloid osmotic pressure and serves as carrier of intermediate metabolites in transport and exchange of tissue products.

Drug Interactions ::

 Interactions None well documented.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note severe anemia, hepatic, or renal impairment.
  • Assess baseline Hct before infusion.
  • Take pulse and BP before and during infusion.
  • Monitor liver and kidney function, Hct, electrolytes, plasma albumin, and total serum protein before and during therapy.
  • Assess for signs of fluid overload before and during infusion.
  • If venous or pulmonary congestion worsens or if hypotension occurs, slow or discontinue infusion and notify physician.
  • Monitor I&O.
  • Monitor for dehydration. Patient may require additional fluids.
  • If patient has sustained injury or has had surgery, observe for new bleeding points as BP increases.
  • Monitor for allergic or pyogenic reactions characterized by fever and chills. If these symptoms occur, discontinue treatment and notify physician.
  • Do not infuse if intravascular volume is normal or increased or if patient has potential for fluid volume overload.

Drug Storage/Management ::

 Administration/Storage

  • Administer by IV infusion only, using accompanying administration set and large-gauge needle or catheter.
  • Give medication as supplied; do not dilute.
  • Administer slowly to prevent too-rapid expansion of blood volume. Exception: May be administered rapidly if there is severe loss of plasma volume.
  • Do not administer if solution is cloudy or sediment is present.
  • Store at room temperature. Do not freeze.

Drug Notes ::

 Patient/Family Education

  • Explain rationale for infusion of drug and need for frequent monitoring.
  • Instruct patient to report the following symptoms to physician: Fever, chills, headache, back pain.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.