Details About Generic Salt ::  Ampicil1

Main Medicine Class:: Antibiotic,penicillin   

(am-pih-SILL-in SO-dee-uhm/sull-BAK-tam SO-dee-uhm)
Unasyn
Class: Antibiotic/penicillin

 

Drugs Class ::

 Action Ampicillin inhibits bacterial cell wall mucopeptide synthesis. Sulbactam inhibits plasmid-medicated beta-lactamase enzymes commonly found in microorganisms resistant to ampicillin.

Indications for Drugs ::

 Indications Treatment of infections of skin and skin structure, intra-abdominal and gynecologic infections caused by susceptible microorganisms, and mixed infections caused by ampicillin-susceptible organisms and beta-lactamase–producing organisms.

Drug Dose ::

 Route/Dosage

ADULTS: IV/IM 1.5 to 3 g q 6 hr not to exceed 4 g/day sulbactam (1.5 g of product contains 0.5 g sulbactam). CHILDREN ³ 1 YEAR OLD (< 40 KG): IV 300 mg/kg/day (200 mg ampicillin/100 mg sulbactam) in divided doses q 6 hr. CHILDREN ³ 40 KG: IV Dose according to adult recommended doses; do not exceed total sulbactam dose of 4 g/day.

Contraindication ::

 Contraindications Hypersensitivity to penicillins, cephalosporins or imipenem.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Hypersensitivity: Reactions range from mild to life-threatening. Use cautiously in cephalosporin-sensitive patients because of possible cross-allergenicity. Superinfection: May result in overgrowth of nonsusceptible bacterial or fungal organisms. Renal impairment: Use cautiously with altered dosing interval.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Thrombophlebitis at injection site. CNS: Dizziness; fatigue; insomnia; reversible hyperactivity. DERM: Urticaria; maculopapular to exfoliative dermatitis; vesicular eruptions; erythema multiforme; skin rashes. EENT: Itchy eyes; laryngospasm; laryngeal edema. GI: Diarrhea; pseudomembranous colitis. GU: Interstitial nephritis (eg, oliguria, proteinuria, hematuria, hyaline casts, pyuria); nephropathy; increased BUN and creatinine; vaginitis. HEMA: Decreased Hgb, Hct, RBC, WBC, neutrophils, lymphocytes, platelets; increased lymphocytes, monocytes, basophils, eosinophils and platelets. META: Elevated serum alkaline phosphatase, glutamic oxaloacetic transaminase, ALT, AST, and LDH; reduced serum albumin and total proteins. OTHER: Pain at injection site; hyperthermia.

Drug Mode of Action ::  

 Action Ampicillin inhibits bacterial cell wall mucopeptide synthesis. Sulbactam inhibits plasmid-medicated beta-lactamase enzymes commonly found in microorganisms resistant to ampicillin.

Drug Interactions ::

 Interactions

Allopurinol: Increases potential for ampicillin-induced skin rash. Contraceptives, oral: May reduce efficacy of oral contraceptives. Tetracyclines: May impair bactericidal effects of ampicillin/sulbactam. INCOMPATIBILITIES: Do not mix with aminoglycosides (eg, gentamicin).

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Review results of culture and sensitivity testing as available.
  • Monitor I&O during therapy.
  • Monitor patient’s condition closely for several hours after administration even if there is no history of known penicillin allergy. Notify physician of any signs and symptoms of hypersensitivity or anaphylactic reaction.
OVERDOSAGE: SIGNS & SYMPTOMS
  Hyperexcitability, convulsive seizures

Drug Storage/Management ::

 Administration/Storage

  • Do not mix in same IV solution with aminoglycosides.
  • Administer IM and IV solutions within 1 hr of reconstitution.
  • Allow foaming to subside before administering IV preparations. Do not administer if discolored or cloudy. Use volumetric IV pump to regulate delivery over 10 to 15 min period.
  • Do not infuse with other IV medications.
  • Do not administer other antibiotics within 1 hr.
  • Do not routinely exceed 14 days of IV therapy in children. Safety and efficacy of IM administration have not been established.
  • Monitor renal function.
  • Rotate IM injection sites.
  • Keep refrigerated after reconstitution. Medication is stable for 2 hr at room temperature, 72 hr if refrigerated.

Drug Notes ::

 Patient/Family Education

  • Explain rationale for hospitalization during course of therapy.
  • Inform patient of potential side effects, and encourage a report of any problems.
  • Encourage patient to increase fluid intake to 2000 to 3000 ml/day, unless contraindicated.
  • Inform diabetic patients that this medication may cause false-positive glucose urine test results, and identify types that will be more reliable.
  • If therapy is changed because of allergic reaction, explain significance of penicillin allergy, and inform of potential sensitivity to cephalosporins.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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