Details About Generic Salt ::  Anistrep

Main Medicine Class:: Thrombolytic enzyme   

(uh-NISS-truh-place)
Eminase
Class: Thrombolytic enzyme

 

Drugs Class ::

 Action Aids in dissolution of blood clots.

Indications for Drugs ::

 Indications Lysis of obstructing coronary thrombi for management of acute MI.

Drug Dose ::

 Route/Dosage

ADULTS: IV 30 U over 2 to 5 min into IV line or vein.

Contraindication ::

 Contraindications Hypersensitivity to streptokinase; active internal bleeding; history of cerebrovascular accident; recent (within 2 mo) intracranial or intraspinal surgery or trauma; intracranial neoplasm; arteriovenous malformation or aneurysm; known bleeding diathesis; uncontrolled hypertension.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Hypersensitivity: Rarely anaphylactic and anaphylactoid reactions (with bronchospasm or angioedema) may occur. Readministration: Because of formation of antistreptokinase antibody, anistreplase may not be effective if administered > 5 day to 6 mo after prior anistreplase or streptokinase therapy or after streptococcal infection.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Arrhythmia and conduction disorders; hypotension. HEMA: Bleeding at puncture site, nonpuncture-site hematoma; hematuria; hemoptysis; GI hemorrhage; intracranial bleeding; mouth and gum hemorrhage; epistaxis; ocular hemorrhage; nonspecific hemorrhage.

Drug Mode of Action ::  

 Action Aids in dissolution of blood clots.

Drug Interactions ::

 Interactions

Anticoagulants (eg, heparin, warfarin) and antiplatelet agents (eg, aspirin, dipyridamole): May increase risk of bleeding. INCOMPATIBILITIES: Do not add to any infusion fluids. Do not add other medications to vial or syringe containing anistreplase.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Identify factors that may contribute to bleeding risk, including baseline coagulation and fibrinolytic activity test results.
  • Determine if and when previous fibrinolytic therapy was administered.
  • Have epinephrine and emergency treatment provisions available during administration of anistreplase.
  • Avoid nonessential handling of patient during anistreplase therapy.
  • If arterial puncture is necessary after administration of anistreplase, it is preferable to use upper extremity vessel that is accessible to manual compression. Apply pressure dressing; check puncture site frequently for evidence of bleeding. Control minor bleeding with manual pressure.
  • Remember that allergic-type reactions may occur in milder forms up to 1 to 2 wk after therapy.
  • Evaluate data from cardiac monitoring, and report any arrhythmias.
  • Monitor diligently for signs or symptoms of internal or surface bleeding. Remember that lab values for coagulation tests and measurements of fibrinolytic activity after anistreplase therapy may be unreliable.
  • Monitor vital signs, especially BP and pulse, because severe hypotension may occur.

Drug Storage/Management ::

 Administration/Storage

  • Reconstitute powder with 5 ml of Sterile Water for Injection. Do not shake vial during reconstitution; try to minimize foaming. Do not further dilute reconstituted anistreplase.
  • Administer 30 U of anistreplase by IV injection over 2 to 5 min.
  • Store lyophilized anistreplase under refrigeration.
  • Discard any reconstituted anistreplase not administered within 30 min of reconstitution.

Drug Notes ::

 Patient/Family Education

  • Explain to patient the need for bedrest and minimal handling of patient.
  • Instruct patient to report the following symptoms to physician: Bruising, bleeding and hypersensitivity reactions (eg, urticaria, flushing, itching, rashes).
  • Caution patient to avoid sudden position changes to prevent orthostatic hypotension.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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