Details About Generic Salt ::  Brimonid

Main Medicine Class:: Antiglaucoma, Alpha-2 adrenergic agonist   

Solution: 0.2%
Alphagan P
Solution: 0.15%
Class: Antiglaucoma, Alpha-2 adrenergic agonist


Drugs Class ::

 Action Reduces aqueous humor production and increases uveoscleral outflow.

Indications for Drugs ::

 Indications Lowers IOP in open-angle glaucoma or ocular hypertension.

Drug Dose ::


Adults and children 2 yr and older: Ophthalmic Instill 1 drop into affected eye(s) tid (approximately 8 hr apart).

Contraindication ::

 Contraindications Coadministration of MAO inhibitors.

Drug Precautions ::


Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy not established in children under 2 yr. Renal or hepatic function impairment: Use with caution. Soft contact lenses: Wait at least 15 min after instilling brimonidine before inserting contact lenses.


Drug Side Effects ::

 Adverse Reactions

CARDIOVASCULAR: Hypertension; palpitations. CNS: Headache; fatigue; drowsiness; dizziness; depression; anxiety; syncope. EENT: Dry mouth; ocular hyperemia, burning, and stinging; blurred vision; foreign body sensation; conjunctival follicles; ocular allergy; ocular pruritus; corneal staining and erosion; photophobia; eyelid erythema and edema; ocular aching and pain; ocular dryness; tearing; conjunctival edema; blepharitis; ocular irritation; conjunctival blanching; abnormal vision; lid crusting; conjunctival hemorrhage; abnormal taste; conjunctival discharge; nasal dryness. GI: GI symptoms. RESPIRATORY: Upper respiratory tract symptoms. OTHER: Asthenia; muscle pain.

Drug Mode of Action ::  

 Action Reduces aqueous humor production and increases uveoscleral outflow.

Drug Interactions ::


Antihypertensives, beta blockers, cardiac glycosides: Brimonidine may reduce pulse and BP; use with caution. CNS depressants (eg, alcohol, anesthetics, barbiturates, opiates, sedative): Additive or potentiating CNS depressant effect. MAO inhibitors: Concurrent use contraindicated. Tricyclic antidepressants: May decrease the effect of brimonidine by altering the metabolism and uptake of circulating amines.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies. Note current or recent (within 14 days) use of MAO inhibitor.
  • Ensure that IOPs have been measured and documented in the patient’s record.
  • Monitor patient for side effects and report to health care provider if noted and significant.

Drug Storage/Management ::


  • Discontinue MAO inhibitors at least 14 days before initiating therapy.
  • Instill 1 drop in the affected eye(s) tid, approximately 8 hr apart.
  • If using other topical ophthalmic drugs, separate each medication by at least 5 min.
  • Store at controlled room temperature. Keep container tightly closed.

Drug Notes ::

 Patient/Family Education

  • Explain name, dose, action, and potential side effects of drug.
  • Advise patient that usual dose is 1 drop in the affected eye(s) tid, approximately 8 hr apart.
  • Teach patient the following proper technique for instilling eye drops: wash hands; do not allow dropper to touch eye. Tilt head back, look up; pull lower eyelid down; instill prescribed number of drops.
  • Close eye for 1 to 2 min and apply gentle pressure to bridge of nose. Do not rub eye.
  • Advise patients who wear contact lenses to remove lenses before instilling this medicine and to wait at least 15 min after instilling eye drop before inserting lenses.
  • Advise patient that if more than 1 topical ophthalmic drug is being used, administer the drugs at least 5 min apart.
  • Advise patient that drug may cause drowsiness or fatigue and to use caution while driving or performing other activities requiring mental alertness.
  • Advise patient to contact eye care physician if eye or eyelid inflammation, irritation, or itching is noted.
  • Remind patient that eye examinations and measurement of IOP will be necessary while using this medication and make sure to keep appointments.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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