Details About Generic Salt ::  Bromphen

Main Medicine Class:: Antihistamine,Alkylamine   

(brome-fen-AIR-uh-meen MAL-ee-ate)
Dimetapp Allergy
Class: Antihistamine/Alkylamine

 

Drugs Class ::

 Action Competitively antagonizes histamine at H1–receptor sites.

Indications for Drugs ::

 Indications Symptomatic relief of perennial and seasonal allergic rhinitis, treatment of vasomotor rhinitis, allergic conjunctivitis; temporary relief of runny nose and sneezing caused by common cold; treatment of allergic and nonallergic pruritic symptoms; temporary relief of mild, uncomplicated urticaria and angioedema; amelioration of allergic reactions to blood or plasma; adjunctive therapy in anaphylactic reactions.

Drug Dose ::

 Route/Dosage

ORAL

ADULTS & CHILDREN (12 YR & OLDER): PO 4 mg q 4 to 6 hr, or 8 to 12 mg of sustained-release form q 8 to 12 hr (maximum 24 mg/day). CHILDREN 6–12 YR: PO 2 mg q 4 to 6 hr (maximum 12 mg/day). Administer sustained-release preparations only at direction of physician. CHILDREN < 6 YR: Use only as directed by physician.

PARENTERAL

ADULTS: SC/IM/IV 10 mg (range 5 to 20 mg) (maximum 40 mg/day). Twice daily administration is usually sufficient (maximum 40 mg/day). CHILDREN < 12 YR: SC 0.5 mg/kg/day or 15 mg/m2/day in 3 or 4 divided doses.

Contraindication ::

 Contraindications Newborn and premature infants; nursing mothers; narrow-angle glaucoma; stenosing peptic ulcer; symptomatic prostatic hypertrophy; asthmatic attack; bladder neck obstruction; pyloroduodenal obstruction; MAOI therapy.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Contraindicated in nursing mothers. Children: Antihistamines may diminish mental alertness; in young child, they may produce paradoxical excitation. Elderly: Greater likelihood of dizziness, excessive sedation, syncope, toxic confusional states and hypotension in patients > 60 years. Dosage reduction may be required. Special-risk patients: Use with caution in patients with predisposition to urinary retention, history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease or hypertension. Avoid use in patients with history of sleep apnea. Hepatic function impairment: Use with caution in patients with cirrhosis or other liver disease. Respiratory disease: Generally not recommended to treat lower respiratory tract symptoms including asthma.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Orthostatic hypotension; palpitations; bradycardia; tachycardia; reflex tachycardia; extrasystoles; faintness CNS: Drowsiness (often transient); sedation; dizziness; syncope; disturbed coordination. GI: Epigastric distress; nausea; vomiting; diarrhea; dry mouth, nose and throat; constipation; change in bowel habits. HEMA: Agranulocytosis. META: Increased appetite; weight gain. RESP: Thickening of bronchial secretions; chest tightness; wheezing; nasal stuffiness; sore throat; respiratory depression. OTHER: Photosensitivity.

Drug Mode of Action ::  

 Action Competitively antagonizes histamine at H1–receptor sites.

Drug Interactions ::

 Interactions

Alcohol, CNS depressants: May cause additive CNS depressant effects. MAO inhibitors: Anticholinergic effects of brompheniramine may increase.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Note history of respiratory problems, hypertension, cardiac arrhythmias, glaucoma, urinary retention, ulcers or GI obstruction.
  • Monitor vital signs closely after establishing a baseline and report irregularities to physician.
  • Monitor intake and output routinely to determine whether patient has urinary retention.
  • Maintain patient’s oral hygiene and hydration to decrease mouth dryness.
  • Closely monitor elderly (> 60 years of age) because of possible intensified effects of medication.
OVERDOSAGE: SIGNS & SYMPTOMS
  Large overdose: Hallucinations, convulsions, death

Drug Storage/Management ::

 Administration/Storage

  • Give tablets with food or milk to reduce GI irritation. Tablets can be crushed and mixed with small amounts of food.
  • Administer sustained-release preparations as supplied. Do not allow patient to crush, break, or chew.
  • Use IM or SC preparations without dilution.
  • Give via slow IV infusion (over 60 min), preferably with patient in recumbent position.

Drug Notes ::

 Patient/Family Education

  • Caution against use if asthmatic symptoms (eg, wheezing) are present.
  • Warn against taking drugs that cause CNS depression such as alcohol, sedatives, or analgesics except as directed by physician.
  • Tell patient to notify physician if heart palpitations are noticed.
  • Instruct patient to report any GI pain or evidence of blood in stool to physician.
  • Caution patient to avoid taking during pregnancy or while breastfeeding unless instructed by physician.
  • Instruct patient to stand slowly from sitting or prone position to avoid dizziness.
  • Advise patient that drug may cause drowsiness and to use caution when driving, operating heavy equipment or performing other tasks requiring mental alertness.
  • Instruct patient to take sips of water frequently or to suck on ice chips, sugarless hard candy, or chewing gum if dry mouth occurs.
  • Advise patient that skin tests performed while taking this drug may yield inaccurate results.

Disclaimer ::

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